TRIM28 and UBE2N

Number of citations of the paper that reports this interaction (PMID 20864041)
40

Data Source:
BioGRID (pull down)

		TRIM28	UBE2N
Gene Name		tripartite motif containing 28	ubiquitin-conjugating enzyme E2N
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin RNA Polymerase II Transcription Factor Complex	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol UBC13-MMS2 Complex UBC13-UEV1A Complex Protein Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding Chromo Shadow Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Poly(A) RNA Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition DNA Repair Transcription Initiation From RNA Polymerase II Promoter Embryo Implantation Gene Expression Protein Ubiquitination Protein Sumoylation Positive Regulation Of Transcription Factor Import Into Nucleus DNA Methylation Involved In Embryo Development Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Oligomerization Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting	Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA Repair Postreplication Repair Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Histone Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Histone Modification Regulation Of Histone Ubiquitination Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination
Pathways		Generic Transcription Pathway	Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Class I MHC mediated antigen processing & presentation IRAK1 recruits IKK complex Innate Immune System ISG15 antiviral mechanism TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Interferon Signaling Cytokine Signaling in Immune system MyD88-independent cascade Antiviral mechanism by IFN-stimulated genes Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Adaptive Immune System
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		62 interactors: CBX1 CBX3 CBX5 CDC34 CDCA4 CEBPB CHAF1A CHD3 ESR1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA3 MAGEA6 MAGED1 MYB NDNL2 NR3C1 NR4A1 NR4A3 PFDN5 PPP4C RNF4 SENP7 SERTAD1 SERTAD2 SETDB1 SIN3A SKI SMARCAD1 SPG7 STAT3 TRIM24 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74	87 interactors: AMFR ARIH2 AURKA BARD1 BCL10 BFAR BIRC3 BIRC8 BRCA1 CADPS2 CHFR CHUK CNOT4 DTX1 DZIP3 F12 HLTF HSP90AA1 LRSAM1 MALT1 MARCH5 MARCH7 MIB1 MIB2 MID1 MKRN3 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB2 PARK2 PELI1 PELI3 PJA2 RBCK1 RC3H2 RFWD3 RIPK1 RNF103 RNF11 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF152 RNF165 RNF167 RNF182 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SLC2A4 STUB1 TMEM189 TMEM189-UBE2V1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TRIM17 TRIM25 TRIM27 TRIM28 TRIM33 TRIM39 TRIM5 TRIM50 TRIM72 UBB UBC UBE2V1 UBE2V2 XIAP ZNRF1 ZNRF2 ZNRF3 ZNRF4
Entrez ID		10155	7334
HPRD ID		03445	04725
Ensembl ID		ENSG00000130726
Uniprot IDs		Q13263	P61088
PDB IDs		1FP0 2RO1 2YVR	1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4EPO 4IP3
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Protein K48-linked Ubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Protein Catabolic Process Cellular Metabolic Process Regulation Of Cellular Process Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Biosynthetic Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein K63-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Cellular Metabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Ubiquitination Metabolic Process Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Cellular Response To Stress Activation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Proteolysis Regulation Of Signaling Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Innate Immune Response Negative Regulation Of Apoptotic Process Regulation Of Innate Immune Response Innate Immune Response Catabolic Process Immune Response Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cell Death
Tagcloud ?		accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2q1 ube2z ubiquitin ubiquitination
Tagcloud (Difference) ?		accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2i ube2q1 ube2z ubiquitin ubiquitination
Tagcloud (Intersection) ?