TRIM28 and MAGEA3

Number of citations of the paper that reports this interaction (PMID 20864041)
40

Data Source:
BioGRID (pull down, two hybrid)

		TRIM28	MAGEA3
Gene Name		tripartite motif containing 28	melanoma antigen family A, 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding Chromo Shadow Domain Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition DNA Repair Transcription Initiation From RNA Polymerase II Promoter Embryo Implantation Gene Expression Protein Ubiquitination Protein Sumoylation Positive Regulation Of Transcription Factor Import Into Nucleus DNA Methylation Involved In Embryo Development Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Oligomerization Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		62 interactors: CBX1 CBX3 CBX5 CDC34 CDCA4 CEBPB CHAF1A CHD3 ESR1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA3 MAGEA6 MAGED1 MYB NDNL2 NR3C1 NR4A1 NR4A3 PFDN5 PPP4C RNF4 SENP7 SERTAD1 SERTAD2 SETDB1 SIN3A SKI SMARCAD1 SPG7 STAT3 TRIM24 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74	4 interactors: DNM1L HLA-DRB1 HTT TRIM28
Entrez ID		10155	4102
HPRD ID		03445	02166
Ensembl ID		ENSG00000130726	ENSG00000221867
Uniprot IDs		Q13263	P43357
PDB IDs		1FP0 2RO1 2YVR	1QEW
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Protein K48-linked Ubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Protein Catabolic Process Cellular Metabolic Process Regulation Of Cellular Process Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Biosynthetic Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process	Protein Oligomerization Positive Regulation Of Transport Protein Complex Assembly Positive Regulation Of Protein Transport Cellular Component Assembly Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Protein Tetramerization Regulation Of Protein Localization Neural Plate Formation Mitochondrial Membrane Fission Dynamin Polymerization Involved In Mitochondrial Fission Negative Regulation Of DNA Demethylation Polysaccharide Assembly With MHC Class II Protein Complex Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Regulation Of Cellular Localization Positive Regulation Of Protein Secretion Mesenchyme Development Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Peroxisome Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Quinolinate Biosynthetic Process Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Negative Regulation Of Synaptic Transmission, Dopaminergic Protein Homooligomerization Convergent Extension Involved In Axis Elongation Lactate Biosynthetic Process Regulation Of Genetic Imprinting DNA Methylation Involved In Embryo Development Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Paraxial Mesoderm Formation Quinolinate Metabolic Process Cellular Response To CGMP Positive Regulation Of Secretion Cellular Protein Complex Assembly Response To CGMP Serotonin Transport Sperm Ejaculation Neural Plate Morphogenesis L-glutamate Import Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Mitochondrial Fission Regulation Of Protein Secretion Mitochondrion Organization Citrulline Metabolic Process Lactate Metabolic Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Tagcloud ?		accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo	acrbp antigens attractive chemoradiation ctag1b ctag2 embedded encountered excision formalin frozen germ homogenous immunogenic immunotherapy lage liposarcoma liposarcomas mainstay myxoid paraffin prame real round ssx2 testicular testis
Tagcloud (Difference) ?		accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo	acrbp antigens attractive chemoradiation ctag1b ctag2 embedded encountered excision formalin frozen germ homogenous immunogenic immunotherapy lage liposarcoma liposarcomas mainstay myxoid paraffin prame real round ssx2 testicular testis
Tagcloud (Intersection) ?