TRIM28 and SMARCAD1

Number of citations of the paper that reports this interaction (PMID 21549307)
21

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TRIM28	SMARCAD1
Gene Name		tripartite motif containing 28	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin RNA Polymerase II Transcription Factor Complex	Heterochromatin Nucleoplasm Nuclear Matrix Site Of Double-strand Break Nuclear Replication Fork
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding Chromo Shadow Domain Binding	Nucleic Acid Binding DNA Binding Helicase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition DNA Repair Transcription Initiation From RNA Polymerase II Promoter Embryo Implantation Gene Expression Protein Ubiquitination Protein Sumoylation Positive Regulation Of Transcription Factor Import Into Nucleus DNA Methylation Involved In Embryo Development Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Oligomerization Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting	Regulation Of DNA Recombination DNA Double-strand Break Processing Chromatin Remodeling Nucleotide Metabolic Process Chromatin Modification ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription, DNA-templated Protein Homooligomerization Chromosome Separation Histone H3 Deacetylation Histone H4 Deacetylation
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS			Capecitabine sensitivity ( 22864933) Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		62 interactors: CBX1 CBX3 CBX5 CDC34 CDCA4 CEBPB CHAF1A CHD3 ESR1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA3 MAGEA6 MAGED1 MYB NDNL2 NR3C1 NR4A1 NR4A3 PFDN5 PPP4C RNF4 SENP7 SERTAD1 SERTAD2 SETDB1 SIN3A SKI SMARCAD1 SPG7 STAT3 TRIM24 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74	2 interactors: PCNA TRIM28
Entrez ID		10155	56916
HPRD ID		03445	11586
Ensembl ID		ENSG00000130726	ENSG00000163104
Uniprot IDs		Q13263	Q9H4L7
PDB IDs		1FP0 2RO1 2YVR
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Protein K48-linked Ubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Protein Catabolic Process Cellular Metabolic Process Regulation Of Cellular Process Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Biosynthetic Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process	Positive Regulation Of DNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of DNA Demethylation Leading Strand Elongation Convergent Extension Involved In Axis Elongation Regulation Of Genetic Imprinting DNA Methylation Involved In Embryo Development DNA Repair Translesion Synthesis Convergent Extension Negative Regulation Of Viral Release From Host Cell Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Viral Release From Host Cell Nuclear DNA Replication Telomere Maintenance Via Recombination DNA Metabolic Process Protein Sumoylation Epithelium Development Embryonic Placenta Morphogenesis Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Axis Elongation Positive Regulation Of DNA Repair Positive Regulation Of Transcription Factor Import Into Nucleus Transcription-coupled Nucleotide-excision Repair Cellular Response To Stress Epithelial To Mesenchymal Transition Positive Regulation Of Nuclease Activity Response To Cadmium Ion DNA Methylation Mismatch Repair Regulation Of DNA Repair Base-excision Repair Tissue Development Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Viral Process Embryo Implantation Telomere Maintenance DNA Modification Regulation Of Transcription Factor Import Into Nucleus Nucleotide-excision Repair Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of DNA Metabolic Process
Tagcloud ?		accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo	associates correctly deacetylases deacetylation ensures establishment faithful g9a glp h3k9 hdac1 heterochromatin kap1 machinery marks methyltransferase modulates pcna pericentric perpetuated posttranslational replication repressive repressors segregation silenced snf specify swi
Tagcloud (Difference) ?		accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo	associates correctly deacetylases deacetylation ensures establishment faithful g9a glp h3k9 hdac1 heterochromatin machinery marks methyltransferase modulates pcna pericentric perpetuated posttranslational replication repressive repressors segregation silenced snf specify swi
Tagcloud (Intersection) ?		kap1