WRN and XRCC5

Number of citations of the paper that reports this interaction (PMID 10783163)
75

Data Source:
HPRD (in vitro, in vivo)

		WRN	XRCC5
Gene Name		Werner syndrome, RecQ helicase-like	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Centrosome MutLalpha Complex	Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex
	Molecular Function	Magnesium Ion Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity ATP-dependent DNA Helicase Activity Helicase Activity Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATPase Activity Manganese Ion Binding Protein Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair Replicative Cell Aging DNA Metabolic Process DNA Replication Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organismal Aging Replication Fork Processing Nucleolus To Nucleoplasm Transport DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis	Telomere Maintenance DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Transcription, DNA-templated Brain Development Cell Proliferation Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Response To Drug Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Hematopoietic Stem Cell Differentiation Cellular Response To Fatty Acid Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency
Pathways			Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System
Drugs
Diseases
GWAS		Exercise treadmill test traits ( 17903301)
Protein-Protein Interactions		26 interactors: ATM ATRX BLM CDKN2A FEN1 H2AFX MDC1 PARP1 PCNA POLB POLD2 POLR1C PRKAR1B PRKDC RAD51 RAD52 RAD54B RPA1 SUMO1 SUMO2 TERF2 TP53 VCP WRNIP1 XRCC5 XRCC6	47 interactors: APEX1 APLF AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 ELF3 GZMA GZMB HSF1 LIG3 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC RBM14 RUNX2 SGOL1 SUMO1 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP2B TYK2 VAV1 WRN XRCC6
Entrez ID		7486	7520
HPRD ID		05212	08935
Ensembl ID		ENSG00000165392	ENSG00000079246
Uniprot IDs		Q14191 Q59F09	P13010
PDB IDs		2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF	1JEQ 1JEY 1Q2Z 1RW2 3RZ9
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair DNA Metabolic Process Cellular Response To Stress DNA Recombination Telomere Maintenance Response To Stress Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Replication DNA-dependent DNA Replication Base-excision Repair Mitotic Recombination Response To Ionizing Radiation Cellular Response To Stimulus DNA Conformation Change Cell Cycle Process Cell Cycle Cellular Response To Ionizing Radiation Response To Stimulus Organelle Organization Telomere Maintenance Via Telomere Lengthening DNA Duplex Unwinding DNA Geometric Change Cellular Metabolic Process Response To Radiation Mitotic Cell Cycle Regulation Of DNA Replication Homeostatic Process Telomere Maintenance Via Semi-conservative Replication Response To Abiotic Stimulus Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Recombinase Assembly DNA Damage Checkpoint Nuclear DNA Replication Telomere Maintenance Via Recombination Macromolecule Biosynthetic Process Response To X-ray DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Mitotic DNA Damage Checkpoint	DNA Metabolic Process Telomere Maintenance DNA Replication DNA Recombination DNA Repair Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Double-strand Break Repair Regulation Of Nitrogen Compound Metabolic Process Response To Stress Chromosome Organization Biosynthetic Process DNA-dependent DNA Replication Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Organelle Organization Regulation Of Metabolic Process Cell Cycle Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Mitotic Recombination Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process DNA Strand Elongation Base-excision Repair Transcription From RNA Polymerase II Promoter Cell Cycle Process Negative Regulation Of Biosynthetic Process
Tagcloud ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Difference) ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Intersection) ?