WRN and PRKDC

Number of citations of the paper that reports this interaction (PMID 11889123)
45

Data Source:
HPRD (in vitro, in vivo)

		WRN	PRKDC
Gene Name		Werner syndrome, RecQ helicase-like	protein kinase, DNA-activated, catalytic polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Centrosome MutLalpha Complex	Nucleoplasm Transcription Factor Complex Nucleolus Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Nonhomologous End Joining Complex
	Molecular Function	Magnesium Ion Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity ATP-dependent DNA Helicase Activity Helicase Activity Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATPase Activity Manganese Ion Binding Protein Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Enzyme Binding Poly(A) RNA Binding
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair Replicative Cell Aging DNA Metabolic Process DNA Replication Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organismal Aging Replication Fork Processing Nucleolus To Nucleoplasm Transport DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Somitogenesis Negative Regulation Of Protein Phosphorylation B Cell Lineage Commitment Pro-B Cell Differentiation T Cell Lineage Commitment DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Protein Modification Process Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Peptidyl-serine Phosphorylation Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Pathways			Nonhomologous End-joining (NHEJ) Cytosolic sensors of pathogen-associated DNA Processing of DNA ends prior to end rejoining STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS		Exercise treadmill test traits ( 17903301)
Protein-Protein Interactions		26 interactors: ATM ATRX BLM CDKN2A FEN1 H2AFX MDC1 PARP1 PCNA POLB POLD2 POLR1C PRKAR1B PRKDC RAD51 RAD52 RAD54B RPA1 SUMO1 SUMO2 TERF2 TP53 VCP WRNIP1 XRCC5 XRCC6	83 interactors: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CHEK1 CHEK2 CHUK CIB1 CTDP1 DCLRE1C E4F1 EIF2S2 EIF4EBP1 ERG GSK3A GSK3B GZMB H2AFX HDAC3 HIST1H1A HIST1H1C HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11A NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R2 PPP6R3 PRKCD PTS RAD17 RBBP8 RNF144A RPA1 RPA2 SGOL1 SP1 SRF THRA THRB TP53 TREX1 UBC USF1 VPRBP WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ
Entrez ID		7486	5591
HPRD ID		05212	02941
Ensembl ID		ENSG00000165392	ENSG00000253729
Uniprot IDs		Q14191 Q59F09	P78527
PDB IDs		2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair DNA Metabolic Process Cellular Response To Stress DNA Recombination Telomere Maintenance Response To Stress Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Replication DNA-dependent DNA Replication Base-excision Repair Mitotic Recombination Response To Ionizing Radiation Cellular Response To Stimulus DNA Conformation Change Cell Cycle Process Cell Cycle Cellular Response To Ionizing Radiation Response To Stimulus Organelle Organization Telomere Maintenance Via Telomere Lengthening DNA Duplex Unwinding DNA Geometric Change Cellular Metabolic Process Response To Radiation Mitotic Cell Cycle Regulation Of DNA Replication Homeostatic Process Telomere Maintenance Via Semi-conservative Replication Response To Abiotic Stimulus Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Recombinase Assembly DNA Damage Checkpoint Nuclear DNA Replication Telomere Maintenance Via Recombination Macromolecule Biosynthetic Process Response To X-ray DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Mitotic DNA Damage Checkpoint	Cellular Response To Stress DNA Repair Cellular Response To DNA Damage Stimulus DNA Recombination DNA Metabolic Process Double-strand Break Repair Response To Stress Immune System Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Immune System Development Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cell Cycle Cellular Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Organelle Organization Cellular Metabolic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Process Cell Death Death Telomere Maintenance Developmental Process Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway DNA Damage Checkpoint Cellular Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Macromolecule Biosynthetic Process Response To Radiation Organ Development Mitotic Cell Cycle Process
Tagcloud ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?