WRN and RAD54B

Number of citations of the paper that reports this interaction (PMID 17118963)
36

Data Source:
BioGRID (far western blotting)

		WRN	RAD54B
Gene Name		Werner syndrome, RecQ helicase-like	RAD54 homolog B (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Centrosome MutLalpha Complex	Nucleus
	Molecular Function	Magnesium Ion Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity ATP-dependent DNA Helicase Activity Helicase Activity Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATPase Activity Manganese Ion Binding Protein Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding	DNA Binding DNA Helicase Activity RNA Helicase Activity ATP Binding DNA Translocase Activity
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair Replicative Cell Aging DNA Metabolic Process DNA Replication Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organismal Aging Replication Fork Processing Nucleolus To Nucleoplasm Transport DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis	Double-strand Break Repair Via Homologous Recombination Mitotic Recombination Reciprocal Meiotic Recombination DNA Duplex Unwinding
Pathways
Drugs
Diseases
GWAS		Exercise treadmill test traits ( 17903301)
Protein-Protein Interactions		26 interactors: ATM ATRX BLM CDKN2A FEN1 H2AFX MDC1 PARP1 PCNA POLB POLD2 POLR1C PRKAR1B PRKDC RAD51 RAD52 RAD54B RPA1 SUMO1 SUMO2 TERF2 TP53 VCP WRNIP1 XRCC5 XRCC6	26 interactors: ANKRD36BP1 ATPAF2 CCDC33 CDC23 CSNK1E DMC1 DYRK2 ENKD1 GMCL1 GORASP2 LNX1 MDM4 MYO15B NIF3L1 NUDT18 PRKAA1 PSMA1 RAD51 RIBC2 SUMO1 TCEANC TCEB3 TRAPPC6A UBE2I WRN ZNF580
Entrez ID		7486	25788
HPRD ID		05212	05049
Ensembl ID		ENSG00000165392	ENSG00000197275
Uniprot IDs		Q14191 Q59F09	O95073 Q9Y620
PDB IDs		2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair DNA Metabolic Process Cellular Response To Stress DNA Recombination Telomere Maintenance Response To Stress Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Replication DNA-dependent DNA Replication Base-excision Repair Mitotic Recombination Response To Ionizing Radiation Cellular Response To Stimulus DNA Conformation Change Cell Cycle Process Cell Cycle Cellular Response To Ionizing Radiation Response To Stimulus Organelle Organization Telomere Maintenance Via Telomere Lengthening DNA Duplex Unwinding DNA Geometric Change Cellular Metabolic Process Response To Radiation Mitotic Cell Cycle Regulation Of DNA Replication Homeostatic Process Telomere Maintenance Via Semi-conservative Replication Response To Abiotic Stimulus Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Recombinase Assembly DNA Damage Checkpoint Nuclear DNA Replication Telomere Maintenance Via Recombination Macromolecule Biosynthetic Process Response To X-ray DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Mitotic DNA Damage Checkpoint	Cell Cycle Cell Cycle Process Cellular Response To Stress Response To Camptothecin Cellular Response To DNA Damage Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Signal Transduction By P53 Class Mediator Protein Modification By Small Protein Conjugation Positive Regulation Of Cellular Metabolic Process Protein Sumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Ionizing Radiation Regulation Of Metabolic Process Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Reciprocal Meiotic Recombination Ubiquitin-dependent Protein Catabolic Process DGDP Catabolic Process DADP Catabolic Process GDP Catabolic Process Response To Brefeldin A Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Positive Regulation Of SUMO Transferase Activity Modification-dependent Protein Catabolic Process Organelle Organization Response To Gamma Radiation Chromosome Segregation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Recombination Nitrogen Compound Metabolic Process Cellular Response To Ionizing Radiation Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteolysis Involved In Cellular Protein Catabolic Process Peptidyl-amino Acid Modification Cellular Response To Hydrogen Peroxide Heterocycle Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteasomal Protein Catabolic Process
Tagcloud ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws	behind checkpoint checkpoints constitutive critically ddr downregulated dynamically facilitating fate fine g2 helicase influences instability integrity ligase limiting limits maintaining mdm2 mdmx override phases scaffold scaffolding snf2 strength tuning
Tagcloud (Difference) ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws	behind checkpoint checkpoints constitutive critically ddr downregulated dynamically facilitating fate fine g2 helicase influences instability integrity ligase limiting limits maintaining mdm2 mdmx override phases scaffold scaffolding snf2 strength tuning
Tagcloud (Intersection) ?