WRN and CDKN2A

Number of citations of the paper that reports this interaction (PMID 15355988)
15

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		WRN	CDKN2A
Gene Name		Werner syndrome, RecQ helicase-like	cyclin-dependent kinase inhibitor 2A
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Centrosome MutLalpha Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Nuclear Body Senescence-associated Heterochromatin Focus Protein Complex
	Molecular Function	Magnesium Ion Binding Y-form DNA Binding Bubble DNA Binding DNA Binding DNA Helicase Activity ATP-dependent DNA Helicase Activity Helicase Activity Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity ATPase Activity Manganese Ion Binding Protein Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding	P53 Binding DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Poly(A) RNA Binding NF-kappaB Binding Ubiquitin-protein Transferase Inhibitor Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair Replicative Cell Aging DNA Metabolic Process DNA Replication Base-excision Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Aging Cell Aging Cellular Response To Starvation Response To UV-C Multicellular Organismal Aging Replication Fork Processing Nucleolus To Nucleoplasm Transport DNA Duplex Unwinding Regulation Of Growth Rate Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Response To Gamma Radiation Nucleic Acid Phosphodiester Bond Hydrolysis	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Negative Regulation Of Cell-matrix Adhesion Transcription, DNA-templated RRNA Processing Negative Regulation Of Protein Kinase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Arrest Ras Protein Signal Transduction Negative Regulation Of Cell Proliferation Apoptotic Mitochondrial Changes Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Growth Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Protein Sumoylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Export From Nucleus Somatic Stem Cell Division Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of Cell Cycle Arrest Cellular Senescence Replicative Senescence Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cellular Senescence
Pathways			Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic Oxidative Stress Induced Senescence Cellular Senescence Oncogene Induced Senescence
Drugs
Diseases
GWAS		Exercise treadmill test traits ( 17903301)	Abdominal aortic aneurysm ( 20622881) Breast cancer ( 23535729 20453838) Coronary artery calcification ( 23561647) Coronary heart disease ( 21626137 21971053 17554300 21378990) Endometriosis ( 23104006) Glioma ( 21531791 19578367) Intracranial aneurysm ( 18997786 20364137) Melanoma ( 21983787 19578364) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Platelet counts ( 22139419) Type 2 diabetes ( 21573907 18372903 20581827 19401414 17463246 17463248 17463249 23209189)
Protein-Protein Interactions		26 interactors: ATM ATRX BLM CDKN2A FEN1 H2AFX MDC1 PARP1 PCNA POLB POLD2 POLR1C PRKAR1B PRKDC RAD51 RAD52 RAD54B RPA1 SUMO1 SUMO2 TERF2 TP53 VCP WRNIP1 XRCC5 XRCC6	94 interactors: ACLY ACTB ACTG1 ACTN4 AHNAK ANKRD12 ARFIP2 BCL2L1 BECN1 CARF CCDC183 CCND1 CCND2 CCNG1 CDC45 CDC5L CDC6 CDC7 CDK4 CDK6 CDKN2AIP CDKN2C CRELD2 CTBP2 DEAF1 E2F1 E4F1 EEF2 EGR1 EPHA3 FN1 GAPDH GGA1 GGA3 GMNN GSPT1 HIF1A HIST3H2BB HNRNPA2B1 HNRNPC HNRNPU HSP90AA1 HSP90AB1 HSPA4 HSPA8 HUWE1 KAT5 MAPK10 MAPK8 MCM10 MCM2 MCM5 MCM6 MDM2 MMRN1 MTR MYC MYL12A NCL NMI ORC4 PCNA PDCD6 PEX19 PLEKHA8 PPP1R9B PRKCA PSMC3 RIN2 RPS7 RUVBL2 SERTAD1 SIVA1 SLC4A1 SMARCA4 SNRPA SNRPB TBRG1 TDRD7 TP63 TPI1 TRIP12 TUBA1A TUBA1C TUBB TUBB4B UBE2A UBE4B USP26 WRN YY1 ZFP91 ZNF227 ZNF410
Entrez ID		7486	1029
HPRD ID		05212	02542
Ensembl ID		ENSG00000165392	ENSG00000147889
Uniprot IDs		Q14191 Q59F09	G3XAG3 K7PML8 P42771 Q8N726
PDB IDs		2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF	1A5E 1BI7 1DC2 2A5E
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair DNA Metabolic Process Cellular Response To Stress DNA Recombination Telomere Maintenance Response To Stress Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Replication DNA-dependent DNA Replication Base-excision Repair Mitotic Recombination Response To Ionizing Radiation Cellular Response To Stimulus DNA Conformation Change Cell Cycle Process Cell Cycle Cellular Response To Ionizing Radiation Response To Stimulus Organelle Organization Telomere Maintenance Via Telomere Lengthening DNA Duplex Unwinding DNA Geometric Change Cellular Metabolic Process Response To Radiation Mitotic Cell Cycle Regulation Of DNA Replication Homeostatic Process Telomere Maintenance Via Semi-conservative Replication Response To Abiotic Stimulus Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Recombinase Assembly DNA Damage Checkpoint Nuclear DNA Replication Telomere Maintenance Via Recombination Macromolecule Biosynthetic Process Response To X-ray DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Mitotic DNA Damage Checkpoint	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle G1/S Transition Of Mitotic Cell Cycle Response To Stress Cellular Response To Stress Regulation Of Metabolic Process Regulation Of Cell Cycle Response To Abiotic Stimulus Cellular Response To DNA Damage Stimulus Response To Radiation Negative Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Mitotic Cell Cycle Cell Division Cellular Nitrogen Compound Metabolic Process Response To UV Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication DNA Replication Initiation Nitrogen Compound Metabolic Process Chromosome Organization Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process DNA Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Radiation Regulation Of Protein Metabolic Process DNA-dependent DNA Replication Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Proliferation Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Stimulus DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation
Tagcloud ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?		cd71 commercially concomitant confirmation diagnosing embedded erythroblasts erythroid erythroleukemia hematological immunocytochemistry immunohistochemical immunostaining localized marrow missing nearly nuclei paraffin polyclonal precursors sections strongest terminus tp53 truncated werner worthy ws	a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Intersection) ?