C8B and C5

Number of citations of the paper that reports this interaction (PMID 3624872)
7

Data Source:
HPRD (in vitro)

		C8B	C5
Gene Name		complement component 8, beta polypeptide	complement component 5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Vesicle Extracellular Vesicular Exosome	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Protein Complex Binding	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Chemokine Activity C5a Anaphylatoxin Chemotactic Receptor Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response	Activation Of MAPK Activity In Utero Embryonic Development Leukocyte Migration Involved In Inflammatory Response Cellular Calcium Ion Homeostasis Chemotaxis Response To Stress Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Norepinephrine Secretion Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Negative Regulation Of Dopamine Secretion Glucose Homeostasis Innate Immune Response Positive Regulation Of Angiogenesis Positive Regulation Of Chemotaxis Cell Chemotaxis Positive Regulation Of Chemokine Secretion
Pathways		Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Terminal pathway of complement Metabolic disorders of biological oxidation enzymes GPCR ligand binding GPCR downstream signaling Regulation of Complement cascade Peptide ligand-binding receptors Complement cascade G alpha (i) signalling events Innate Immune System
Drugs			Intravenous Immunoglobulin Eculizumab
Diseases
GWAS			Rheumatoid arthritis ( 20453842 19503088)
Protein-Protein Interactions		3 interactors: C5 C8A CLU	9 interactors: C2 C3 C5AR1 C6 C7 C8B CPB2 CPN1 CREB3L1
Entrez ID		732	727
HPRD ID		00410	00405
Ensembl ID		ENSG00000021852	ENSG00000106804
Uniprot IDs		B7Z550 B7Z555 P07358	P01031
PDB IDs		3OJY	1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Complement Activation, Alternative Pathway Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Cytolysis Regulation Of Complement Activation Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Regulation Of Acute Inflammatory Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Inflammatory Response Central Nervous System Myelin Maintenance Regulation Of Tau-protein Kinase Activity Negative Regulation Of Dopamine Secretion Negative Regulation Of Protein Homooligomerization Positive Regulation Of Cytokine Production Immune System Process Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Regulation Of Protein Metabolic Process Regulation Of Protein Processing Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Protein Oligomerization Positive Regulation Of Protein Kinase Activity Positive Regulation Of Chemokine Secretion Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Kinase Activity Regulation Of Cytokine Production Regulation Of Norepinephrine Secretion Chaperone-mediated Protein Complex Assembly Microglial Cell Activation	Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Regulation Of Protein Processing Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Complement Activation, Alternative Pathway Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Inflammatory Response Positive Regulation Of Immune Response Cytolysis Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Stress Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Apoptotic Cell Clearance Innate Immune Response Regulation Of Apoptotic Cell Clearance Positive Regulation Of Humoral Immune Response Positive Regulation Of Protein Processing Immune System Process Response To Stimulus Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Organ Regeneration Complement Component C5a Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Endocytosis Positive Regulation Of Type IIa Hypersensitivity Protein Metabolic Process Cellular Chemical Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Extracellular Matrix Constituent Secretion Negative Regulation Of Hepatocyte Proliferation Liver Regeneration Bradykinin Catabolic Process Cell Proliferation In Hindbrain Complement Receptor Mediated Signaling Pathway Cellular Homeostasis
Tagcloud ?			autophosphorylation cleavage cleave cleaved convertases d4 endoproteolytic exclude furin greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive
Tagcloud (Difference) ?			autophosphorylation cleavage cleave cleaved convertases d4 endoproteolytic exclude furin greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive
Tagcloud (Intersection) ?