C8B

Gene Name		complement component 8, beta polypeptide
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Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Complex Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response
Pathways		Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: C5 C8A CLU
Entrez ID		732
HPRD ID		00410
Ensembl ID		ENSG00000021852
Uniprot IDs		B7Z550 B7Z555 P07358
PDB IDs		3OJY
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Complement Activation, Alternative Pathway Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Cytolysis Regulation Of Complement Activation Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Regulation Of Acute Inflammatory Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Inflammatory Response Central Nervous System Myelin Maintenance Regulation Of Tau-protein Kinase Activity Negative Regulation Of Dopamine Secretion Negative Regulation Of Protein Homooligomerization Positive Regulation Of Cytokine Production Immune System Process Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Regulation Of Protein Metabolic Process Regulation Of Protein Processing Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Protein Oligomerization Positive Regulation Of Protein Kinase Activity Positive Regulation Of Chemokine Secretion Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Kinase Activity Regulation Of Cytokine Production Regulation Of Norepinephrine Secretion Chaperone-mediated Protein Complex Assembly Microglial Cell Activation
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