C8B and C8A

Number of citations of the paper that reports this interaction (PMID 10387094)
1

Data Source:
HPRD (in vitro, in vivo)

		C8B	C8A
Gene Name		complement component 8, beta polypeptide	complement component 8, alpha polypeptide
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Vesicle Extracellular Vesicular Exosome	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Complex Binding	Complement Binding Protein Complex Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response
Pathways		Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System	Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: C5 C8A CLU	4 interactors: C8B C8G C9 CD59
Entrez ID		732	731
HPRD ID		00410	00409
Ensembl ID		ENSG00000021852	ENSG00000157131
Uniprot IDs		B7Z550 B7Z555 P07358	P07357
PDB IDs		3OJY	2QOS 2QQH 2RD7 3OJY
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Complement Activation, Alternative Pathway Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Cytolysis Regulation Of Complement Activation Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Regulation Of Acute Inflammatory Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Negative Regulation Of Macrophage Chemotaxis Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Inflammatory Response Central Nervous System Myelin Maintenance Regulation Of Tau-protein Kinase Activity Negative Regulation Of Dopamine Secretion Negative Regulation Of Protein Homooligomerization Positive Regulation Of Cytokine Production Immune System Process Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Regulation Of Protein Metabolic Process Regulation Of Protein Processing Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Protein Oligomerization Positive Regulation Of Protein Kinase Activity Positive Regulation Of Chemokine Secretion Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Kinase Activity Regulation Of Cytokine Production Regulation Of Norepinephrine Secretion Chaperone-mediated Protein Complex Assembly Microglial Cell Activation	Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation, Alternative Pathway Cytolysis Regulation Of Inflammatory Response Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Innate Immune Response Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Immune Response Positive Regulation Of Immune System Process Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Immune Response Regulation Of Immune System Process Defense Response Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Immune Response Negative Regulation Of Activation Of Membrane Attack Complex Response To Stress Hemolysis By Symbiont Of Host Erythrocytes Negative Regulation Of Complement Activation Killing Of Cells Of Other Organism Regulation Of Metabolic Process Positive Regulation Of T Cell Proliferation Response To Stimulus Interaction With Host Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Immune Response Regulation Of T Cell Proliferation
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