C5 and C6

Number of citations of the paper that reports this interaction (PMID 2808363)
12

Data Source:
HPRD (in vitro)

		C5	C6
Gene Name		complement component 5	complement component 6
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Membrane Attack Complex Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Chemokine Activity C5a Anaphylatoxin Chemotactic Receptor Binding	Protein Binding
	Biological Process	Activation Of MAPK Activity In Utero Embryonic Development Leukocyte Migration Involved In Inflammatory Response Cellular Calcium Ion Homeostasis Chemotaxis Response To Stress Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Negative Regulation Of Norepinephrine Secretion Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Negative Regulation Of Dopamine Secretion Glucose Homeostasis Innate Immune Response Positive Regulation Of Angiogenesis Positive Regulation Of Chemotaxis Cell Chemotaxis Positive Regulation Of Chemokine Secretion	In Utero Embryonic Development Positive Regulation Of Activation Of Membrane Attack Complex Complement Activation Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Angiogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Terminal pathway of complement Metabolic disorders of biological oxidation enzymes GPCR ligand binding GPCR downstream signaling Regulation of Complement cascade Peptide ligand-binding receptors Complement cascade G alpha (i) signalling events Innate Immune System	Regulation of Complement cascade Complement cascade Terminal pathway of complement Innate Immune System
Drugs		Intravenous Immunoglobulin Eculizumab
Diseases
GWAS		Rheumatoid arthritis ( 20453842 19503088)	Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		9 interactors: C2 C3 C5AR1 C6 C7 C8B CPB2 CPN1 CREB3L1	4 interactors: C5 F2 MGEA5 SART3
Entrez ID		727	729
HPRD ID		00405	01956
Ensembl ID		ENSG00000106804	ENSG00000039537
Uniprot IDs		P01031	P13671
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S	3T5O 4A5W 4E0S
Enriched GO Terms of Interacting Partners?		Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Regulation Of Protein Processing Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Complement Activation, Alternative Pathway Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Inflammatory Response Positive Regulation Of Immune Response Cytolysis Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Stress Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Apoptotic Cell Clearance Innate Immune Response Regulation Of Apoptotic Cell Clearance Positive Regulation Of Humoral Immune Response Positive Regulation Of Protein Processing Immune System Process Response To Stimulus Positive Regulation Of Phagocytosis Regulation Of Phagocytosis Organ Regeneration Complement Component C5a Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Endocytosis Positive Regulation Of Type IIa Hypersensitivity Protein Metabolic Process Cellular Chemical Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Extracellular Matrix Constituent Secretion Negative Regulation Of Hepatocyte Proliferation Liver Regeneration Bradykinin Catabolic Process Cell Proliferation In Hindbrain Complement Receptor Mediated Signaling Pathway Cellular Homeostasis	Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cellular Protein Metabolic Process Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Ion Transport Regulation Of Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Calcium Ion Transport Positive Regulation Of Transport Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Histone Deubiquitination Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Ion Homeostasis Protein Activation Cascade Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Cardiac Muscle Adaptation Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Positive Regulation Of Protein Secretion Positive Regulation Of Ion Transport Positive Regulation Of Metabolic Process Leukocyte Migration Positive Regulation Of Intracellular Transport Protein Deglycosylation Negative Regulation Of Protein Glycosylation Homeostatic Process Negative Regulation Of Dopamine Secretion Cellular Calcium Ion Homeostasis Regulation Of Protein Deubiquitination Calcium Ion Homeostasis Positive Regulation Of Secretion Positive Regulation Of Protein Transport Positive Regulation Of Growth Hormone Secretion DATP Metabolic Process Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Norepinephrine Secretion Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Secretion Positive Regulation Of Chemokine Secretion Regulation Of Growth Hormone Secretion Regulation Of Protein Glycosylation Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Fibrinolysis Regulation Of Protein Processing Cellular Metal Ion Homeostasis
Tagcloud ?		autophosphorylation cleavage cleave cleaved convertases d4 endoproteolytic exclude furin greatly heterodimers ht29 idea igfs immunocytometry ir ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive	appeared confluence confluent conversely culture d differentially exponential glioma half igf ir ka largest late later mannose phase phases phosphate post scatchard seeding showing stage stages statistically stopped values
Tagcloud (Difference) ?		autophosphorylation cleavage cleave cleaved convertases d4 endoproteolytic exclude furin greatly heterodimers ht29 idea igfs immunocytometry ir3 kda lovo participate posttranslational processed proprotein restore totally trypsin unable unprocessed unresponsive	appeared confluence confluent conversely culture d differentially exponential glioma half igf ka largest late later mannose phase phases phosphate post scatchard seeding showing stage stages statistically stopped values
Tagcloud (Intersection) ?		ir