ARRB2 and PTAFR

Number of citations of the paper that reports this interaction (PMID 11729201)
9

Data Source:
HPRD (in vivo, in vitro)

		ARRB2	PTAFR
Gene Name		arrestin, beta 2	platelet-activating factor receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Coated Pit Postsynaptic Density Basolateral Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Postsynaptic Membrane	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Type 1 Angiotensin Receptor Binding D1 Dopamine Receptor Binding Follicle-stimulating Hormone Receptor Binding Type 2A Serotonin Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Kinase B Binding Mitogen-activated Protein Kinase Binding 14-3-3 Protein Binding	Lipopolysaccharide Binding Lipopolysaccharide Receptor Activity G-protein Coupled Receptor Activity Platelet Activating Factor Receptor Activity Phospholipid Binding G-protein Coupled Purinergic Nucleotide Receptor Activity
	Biological Process	G-protein Coupled Receptor Internalization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Brain Development Blood Coagulation Adult Walking Behavior Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Follicle-stimulating Hormone Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of DNA Biosynthetic Process	Cytokine Production Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Inositol Trisphosphate Biosynthetic Process G-protein Coupled Purinergic Nucleotide Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Interferon-gamma-mediated Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by Wnt beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 WNT5A-dependent internalization of FZD4 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Activation of SMO FBXW7 Mutants and NOTCH1 in Cancer	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Interferon Signaling Cytokine Signaling in Immune system Metabolic disorders of biological oxidation enzymes GPCR ligand binding Interferon gamma signaling G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ADRB2 AGTR1 AP1B1 AP2M1 ARF6 AVPR2 C5AR1 CDC42 CLTC CSNK2A1 CSNK2A2 CXCR4 CYTH2 DVL2 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MDM2 MED8 NDUFS7 NFKBIA NTS NTSR1 OPRD1 OXTR PARK2 PDE4D PTAFR PTGDS RAF1 RALGDS SLC9A5 SMARCC2 STC2 TGFBR3 TRH USP33	9 interactors: ARR3 ARRB1 ARRB2 CALM1 GORAB GTPBP3 RGS4 SPATA24 TYK2
Entrez ID		409	5724
HPRD ID		00147	01422
Ensembl ID		ENSG00000141480	ENSG00000169403
Uniprot IDs		K7ENA6 P32121 Q59EM5	A8K7N8 P25105
PDB IDs			2B0X
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signaling Signal Transduction Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Response To External Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Stress-activated MAPK Cascade Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Response To Organic Substance Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Chemotaxis Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Locomotion Immune System Process Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Fc Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Apoptotic Process Response To Stress Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Regulation Of MAP Kinase Activity Response To Lipid	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Internalization Regulation Of Protein Phosphorylation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Detection Of Abiotic Stimulus Regulation Of Phosphorylation Platelet Activation Regulation Of Receptor Internalization Regulation Of Phosphorus Metabolic Process Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Cellular Protein Metabolic Process Receptor Internalization Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Receptor Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Calcium Ion Transport Phototransduction Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Endocytosis Detection Of Light Stimulus Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Detection Of Stimulus Regulation Of Body Fluid Levels Vesicle-mediated Transport Positive Regulation Of ERK1 And ERK2 Cascade Wound Healing Regulation Of MAPK Cascade Regulation Of Signal Transduction Notch Signaling Pathway Regulation Of Protein Binding Endocytosis Cell Activation Response To Wounding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?		17p13 22q11 adrbk2 adrenergic ark ark1 ark2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag	10d a2a adenosine adora1 adora2a adora3 b4 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl purinergic sell selplg slc29a1 slc29a2
Tagcloud (Difference) ?		17p13 22q11 adrbk2 adrenergic ark ark1 ark2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag	10d a2a adenosine adora1 adora2a adora3 b4 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl purinergic sell selplg slc29a1 slc29a2
Tagcloud (Intersection) ?