STK11 and STRADA

Number of citations of the paper that reports this interaction (PMID 12805220)
83

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)
HPRD (two hybrid, in vivo, in vitro)

		STK11	STRADA
Gene Name		serine/threonine kinase 11	STE20-related kinase adaptor alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane TCR Signalosome Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity Protein Complex Binding	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Energy Reserve Metabolic Process Protein Phosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatid Development Axonogenesis Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Ionizing Radiation Establishment Of Cell Polarity Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Response To Glucagon Response To Lipid TCR Signalosome Assembly Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Anoikis Small Molecule Metabolic Process Positive Thymic T Cell Selection Positive Regulation Of Gluconeogenesis Protein Autophosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Protein Heterooligomerization Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Mitotic Cell Cycle Protein Phosphorylation Protein Export From Nucleus Cell Cycle Arrest Insulin Receptor Signaling Pathway Activation Of Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Insulin receptor signalling cascade Integration of energy metabolism IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Insulin receptor signalling cascade IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS		Alzheimer's disease ( 22005930)
Protein-Protein Interactions		29 interactors: APP ATM CAB39 CDC37 ETV4 MAPRE1 MARK1 MARK2 MARK4 MOB4 PARD3 PRKAA1 PRKAA2 PRKACA PTEN RPS6KA3 RPS6KA5 RPS6KB1 SIK1 SIRT1 SMARCA4 SNRK SPDEF STK11IP STRADA STRADB TNIP2 TP53 UBE2D2	3 interactors: CAB39 STK11 XPO1
Entrez ID		6794	92335
HPRD ID		03740	14332
Ensembl ID		ENSG00000118046	ENSG00000266173
Uniprot IDs		Q15831	Q7RTN6 Q86YC8
PDB IDs		2WTK	1UPK 2WTK 3GNI
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Protein Phosphorylation Cell Cycle Cellular Protein Modification Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Metabolic Process Cell Cycle Arrest Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Cell Death Histone Phosphorylation Regulation Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Histone-serine Phosphorylation Cellular Response To Organic Substance Regulation Of Protein Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Protein Metabolic Process Cell Differentiation Signaling Response To Insulin Response To Peptide Hormone Cell Communication Response To External Stimulus Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Regulation Of Signal Transduction	Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Cycle Protein Heterooligomerization Cell Cycle Arrest Insulin Receptor Signaling Pathway TCR Signalosome Assembly Regulation Of Cellular Response To Growth Factor Stimulus Cell Cycle Cellular Response To Insulin Stimulus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Activation Of Protein Kinase Activity Response To Insulin Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Rubidium Ion Transport Anoikis Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To UV-B Ribosomal Large Subunit Export From Nucleus Organelle Localization Protein Oligomerization Negative Regulation Of Cell Cycle Response To Peptide Hormone Ribosomal Subunit Export From Nucleus Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Thymic T Cell Selection Response To Peptide Response To Organic Substance Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Transferase Activity Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Hormone Stimulus Cellular Hypotonic Response Golgi Localization Positive Regulation Of Peptidyl-threonine Phosphorylation Response To UV-B Hypotonic Response Positive Regulation Of Gluconeogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Tagcloud ?		alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue	200mg acetonitrile ammonium analyte ascending aspec automatic automatically c18 cartridges chronobiological circadian deviation gilson insomnia melatonin neu neup11 p11 phasing precision processor purospher put qcss quantification spe true xl
Tagcloud (Difference) ?		alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue	200mg acetonitrile ammonium analyte ascending aspec automatic automatically c18 cartridges chronobiological circadian deviation gilson insomnia melatonin neu neup11 p11 phasing precision processor purospher put qcss quantification spe true xl
Tagcloud (Intersection) ?