STK11 and RPS6KA5

Number of citations of the paper that reports this interaction (PMID 11297520)
77

Data Source:
HPRD (in vitro)

		STK11	RPS6KA5
Gene Name		serine/threonine kinase 11	ribosomal protein S6 kinase, 90kDa, polypeptide 5
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane TCR Signalosome Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity Protein Complex Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Energy Reserve Metabolic Process Protein Phosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatid Development Axonogenesis Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Ionizing Radiation Establishment Of Cell Polarity Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Response To Glucagon Response To Lipid TCR Signalosome Assembly Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Anoikis Small Molecule Metabolic Process Positive Thymic T Cell Selection Positive Regulation Of Gluconeogenesis Protein Autophosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Protein Heterooligomerization Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Negative Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Histone Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Histone Acetylation Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Histone H2A-S1 Phosphorylation Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway
Pathways		Insulin receptor signalling cascade Integration of energy metabolism IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation L1CAM interactions Recycling pathway of L1 Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Alzheimer's disease ( 22005930)	Bone mineral density ( 22504420)
Protein-Protein Interactions		29 interactors: APP ATM CAB39 CDC37 ETV4 MAPRE1 MARK1 MARK2 MARK4 MOB4 PARD3 PRKAA1 PRKAA2 PRKACA PTEN RPS6KA3 RPS6KA5 RPS6KB1 SIK1 SIRT1 SMARCA4 SNRK SPDEF STK11IP STRADA STRADB TNIP2 TP53 UBE2D2	59 interactors: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CSNK2B DDAH2 DNAJC11 EIF4E EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 HIST1H1B HIST1H3E HIST2H2BE HIST2H3C HIST2H4A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 HMGN1 HSPB1 HSPB2 IL17RB ITSN1 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZAK ZNF775
Entrez ID		6794	9252
HPRD ID		03740	06789
Ensembl ID		ENSG00000118046	ENSG00000100784
Uniprot IDs		Q15831	B7Z2Y5 O75582 Q9UG98
PDB IDs		2WTK	1VZO 3KN5 3KN6
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Protein Phosphorylation Cell Cycle Cellular Protein Modification Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Metabolic Process Cell Cycle Arrest Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Cell Death Histone Phosphorylation Regulation Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Histone-serine Phosphorylation Cellular Response To Organic Substance Regulation Of Protein Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Protein Metabolic Process Cell Differentiation Signaling Response To Insulin Response To Peptide Hormone Cell Communication Response To External Stimulus Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Regulation Of Signal Transduction	Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Defense Response Enzyme Linked Receptor Protein Signaling Pathway Response To Abiotic Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Stress Neurotrophin Signaling Pathway Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Cell Differentiation Innate Immune Response Immune Response Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor System Development Regulation Of Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Anatomical Structure Development Response To Hormone Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Multicellular Organismal Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Immune System Process Chromatin Organization Chromosome Organization Generation Of Neurons TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Stress-activated MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue	27a 5p arrays bioinformatics cbl changed creb creb1 directive erk2 escc esophageal folds grb2 mapk1 mapk14 microrna mir mirna mirnas ngfr options prediction pt1n0 sos1 sprouty spry2 taqman verify
Tagcloud (Difference) ?		alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue	27a 5p arrays bioinformatics cbl changed creb creb1 directive erk2 escc esophageal folds grb2 mapk1 mapk14 microrna mir mirna mirnas ngfr options prediction pt1n0 sos1 sprouty spry2 taqman verify
Tagcloud (Intersection) ?