STRADA and XPO1

Number of citations of the paper that reports this interaction (PMID 22833565)
7

Data Source:
BioGRID (unspecified method)

		STRADA	XPO1
Gene Name		STE20-related kinase adaptor alpha	exportin 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Ribonucleoprotein Complex Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity	RNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Ran GTPase Binding Protein Transporter Activity Protein Domain Specific Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Protein Export From Nucleus Cell Cycle Arrest Insulin Receptor Signaling Pathway Activation Of Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Centrosome Duplication Viral Process Viral Life Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Nucleus Regulation Of Protein Catabolic Process Response To Drug Regulation Of Protein Export From Nucleus MRNA Transport Intracellular Transport Of Virus
Pathways		Insulin receptor signalling cascade IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Loss of Function of TGFBR2 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGF-beta receptor signaling activates SMADs Influenza Life Cycle Export of Viral Ribonucleoproteins from Nucleus RNF mutants show enhanced WNT signaling and proliferation Regulation of mRNA stability by proteins that bind AU-rich elements TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Influenza Infection Late Phase of HIV Life Cycle Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Mitotic Prometaphase Separation of Sister Chromatids HIV Infection Rev-mediated nuclear export of HIV RNA G2/M Transition Mitotic Anaphase TGFBR1 LBD Mutants in Cancer HuR stabilizes mRNA deactivation of the beta-catenin transactivating complex M Phase HIV Life Cycle Rev-mediated nuclear export of HIV RNA Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN NEP/NS2 Interacts with the Cellular Export Machinery Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Interactions of Rev with host cellular proteins Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CAB39 STK11 XPO1	72 interactors: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 CCND1 CDC25A CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 IRF5 KIF17 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA PXN RAN RANBP1 RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SNUPN SOX2 STAT1 STRADA TERF2IP TERT TOP2A TOP2B TP73
Entrez ID		92335	7514
HPRD ID		14332	03975
Ensembl ID		ENSG00000266173	ENSG00000082898
Uniprot IDs		Q7RTN6 Q86YC8	B3KWD0 O14980
PDB IDs		1UPK 2WTK 3GNI	1W9C 2L1L 3GB8 4BSM 4BSN
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Cycle Protein Heterooligomerization Cell Cycle Arrest Insulin Receptor Signaling Pathway TCR Signalosome Assembly Regulation Of Cellular Response To Growth Factor Stimulus Cell Cycle Cellular Response To Insulin Stimulus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Activation Of Protein Kinase Activity Response To Insulin Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Rubidium Ion Transport Anoikis Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To UV-B Ribosomal Large Subunit Export From Nucleus Organelle Localization Protein Oligomerization Negative Regulation Of Cell Cycle Response To Peptide Hormone Ribosomal Subunit Export From Nucleus Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Thymic T Cell Selection Response To Peptide Response To Organic Substance Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Transferase Activity Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Hormone Stimulus Cellular Hypotonic Response Golgi Localization Positive Regulation Of Peptidyl-threonine Phosphorylation Response To UV-B Hypotonic Response Positive Regulation Of Gluconeogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	Cell Cycle Cell Cycle Process Nucleocytoplasmic Transport Mitotic Cell Cycle Nuclear Transport Mitotic Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Organelle Organization Cytoplasmic Transport Nuclear Export Positive Regulation Of Gene Expression Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Export From Nucleus Intracellular Transport Response To Organic Substance Negative Regulation Of Phosphorylation RNA Transport RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Kinase Activity Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity RNA Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Process Regulation Of Kinase Activity Regulation Of Cell Cycle Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		200mg acetonitrile ammonium analyte ascending aspec automatic automatically c18 cartridges chronobiological circadian deviation gilson insomnia melatonin neu neup11 p11 phasing precision processor purospher put qcss quantification spe true xl	accounting atm bioinformatics birc3 concordance confirmation conservative cutoff discordant eventually haloplex hiseq ighv ighv3 klhl6 lymphocytic myd88 next notch1 pot1 precision recurrently repeating reproducible sanger sequencing sf3b1 stand unmutated
Tagcloud (Difference) ?		200mg acetonitrile ammonium analyte ascending aspec automatic automatically c18 cartridges chronobiological circadian deviation gilson insomnia melatonin neu neup11 p11 phasing processor purospher put qcss quantification spe true xl	accounting atm bioinformatics birc3 concordance confirmation conservative cutoff discordant eventually haloplex hiseq ighv ighv3 klhl6 lymphocytic myd88 next notch1 pot1 recurrently repeating reproducible sanger sequencing sf3b1 stand unmutated
Tagcloud (Intersection) ?		precision