SLC6A1 and STX1A

Number of citations of the paper that reports this interaction (PMID 11017172)
28

Data Source:
HPRD (in vivo, in vitro)

		SLC6A1	STX1A
Gene Name		solute carrier family 6 (neurotransmitter transporter), member 1	syntaxin 1A (brain)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Axon	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
	Molecular Function	Neurotransmitter:sodium Symporter Activity Gamma-aminobutyric Acid:sodium Symporter Activity	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Transport Synaptic Transmission Neurotransmitter Secretion Learning Response To Toxic Substance Response To Sucrose Response To Lead Ion Positive Regulation Of Gamma-aminobutyric Acid Secretion Response To Purine-containing Compound Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Cocaine Protein Homooligomerization Response To Calcium Ion Gamma-aminobutyric Acid Import Transmembrane Transport	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Na+/Cl- dependent neurotransmitter transporters Neurotransmitter Release Cycle Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds GABA synthesis, release, reuptake and degradation SLC-mediated transmembrane transport Transmission across Chemical Synapses Reuptake of GABA	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses
Drugs		Tiagabine Guvacine
Diseases
GWAS		Conduct disorder (interaction) ( 18846501) Response to Vitamin E supplementation ( 22437554)
Protein-Protein Interactions		1 interactors: STX1A	58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18
Entrez ID		6529	6804
HPRD ID		00664	01721
Ensembl ID		ENSG00000157103	ENSG00000106089
Uniprot IDs		P30531	A8MZ54 Q16623 Q75ME0
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Docking Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Response To Gravity Positive Regulation Of Neurotransmitter Secretion Glutamate Secretion Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Synaptic Vesicle Transport Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Vesicle Fusion Synaptic Vesicle Exocytosis Acid Secretion Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Organelle Fusion Regulation Of Postsynaptic Membrane Potential Vesicle Docking Dicarboxylic Acid Transport Membrane Docking Neurotransmitter Secretion Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Membrane Depolarization Membrane Fusion Energy Reserve Metabolic Process Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Amino Acid Transport Neurotransmitter Transport Regulation Of Insulin Secretion Establishment Of Vesicle Localization Pathogenesis Vesicle Organization Vesicle Localization Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Regulation Of Membrane Potential Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Positive Regulation Of Secretion Establishment Of Organelle Localization Regulation Of Protein Complex Assembly Exocytosis Regulation Of Vesicle-mediated Transport	Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport
Tagcloud ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic htr2a latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic trajectories variations	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Difference) ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic htr2a latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic trajectories variations	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Intersection) ?