STX1A and SLC6A9

Number of citations of the paper that reports this interaction (PMID 10722844)
7

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		STX1A	SLC6A9
Gene Name		syntaxin 1A (brain)	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding	Neurotransmitter:sodium Symporter Activity Glycine:sodium Symporter Activity
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Amino Acid Transmembrane Transport Transport Neurotransmitter Transport Glycine Transport Transmembrane Transport
Pathways		Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses	Na+/Cl- dependent neurotransmitter transporters Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport
Drugs			Glycine
Diseases
GWAS
Protein-Protein Interactions		58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18	3 interactors: GABRR1 PRKCA STX1A
Entrez ID		6804	6536
HPRD ID		01721	03010
Ensembl ID		ENSG00000106089	ENSG00000196517
Uniprot IDs		A8MZ54 Q16623 Q75ME0	B7Z3W8 P48067
PDB IDs
Enriched GO Terms of Interacting Partners?		Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport	Synaptic Transmission Cell-cell Signaling Energy Reserve Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Insulin Secretion Histone H3-T6 Phosphorylation Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Energy Derivation By Oxidation Of Organic Compounds Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Secretion Generation Of Precursor Metabolites And Energy Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Response To Gravity Positive Regulation Of Neurotransmitter Secretion Regulation Of Protein Transport Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Regulation Of Secretion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Anion Transport Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Establishment Of Protein Localization Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Glutamate Secretion Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Protein Localization Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Regulation Of Platelet Activation Membrane Organization Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Regulation Of Synaptic Vesicle Exocytosis
Tagcloud ?		colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Difference) ?		colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Intersection) ?