STX1A and STXBP5

Number of citations of the paper that reports this interaction (PMID 9620695)
60

Data Source:
HPRD (in vitro)

		STX1A	STXBP5
Gene Name		syntaxin 1A (brain)	syntaxin binding protein 5 (tomosyn)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex	Cytoplasm Acetylcholine-gated Channel Complex Synaptic Vesicle Cell Junction Cytoplasmic Vesicle Membrane
	Molecular Function	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding	Syntaxin-1 Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Exocytosis Regulation Of Gene Expression Protein Transport Regulation Of Exocytosis Regulation Of Blood Coagulation Positive Regulation Of Exocytosis
Pathways		Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Coagulation factor levels ( 20231535)
Protein-Protein Interactions		58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18	3 interactors: SNAP23 STX1A STX4
Entrez ID		6804	134957
HPRD ID		01721	06845
Ensembl ID		ENSG00000106089
Uniprot IDs		A8MZ54 Q16623 Q75ME0	Q5T5C0
PDB IDs
Enriched GO Terms of Interacting Partners?		Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport	Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Fusion Synaptic Vesicle Exocytosis Organelle Fusion Neurotransmitter Secretion Synaptic Vesicle Transport Membrane Fusion Regulation Of Neurotransmitter Levels Neurotransmitter Transport Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Establishment Of Organelle Localization Exocytosis Organelle Localization Secretion By Cell Synaptic Transmission Positive Regulation Of Exocytosis Secretion Vesicle Docking Post-Golgi Vesicle-mediated Transport Membrane Docking Membrane Organization Cell-cell Signaling Positive Regulation Of Synaptic Transmission Regulation Of Exocytosis Regulation Of Insulin Secretion Protein Transport Vesicle-mediated Transport Positive Regulation Of Eosinophil Degranulation Establishment Of Protein Localization Regulation Of Peptide Hormone Secretion Intracellular Transport Regulation Of Hormone Secretion Golgi Vesicle Transport Regulation Of Synaptic Transmission Protein Localization Positive Regulation Of Secretion Cellular Protein Complex Assembly Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Regulation Of Protein Secretion Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Immunoglobulin Secretion Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Cellular Localization Synaptic Vesicle Priming SNARE Complex Assembly Histamine Secretion By Mast Cell
Tagcloud ?		colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d tongue tumorigenic validate
Tagcloud (Difference) ?		colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d tongue tumorigenic validate
Tagcloud (Intersection) ?