BLM and TOPBP1

Number of citations of the paper that reports this interaction (PMID 24239288)
1

Data Source:
BioGRID (pull down)

		BLM	TOPBP1
Gene Name		Bloom syndrome, RecQ helicase-like	topoisomerase (DNA) II binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Lateral Element Male Germ Cell Nucleus Nucleus Replication Fork Nucleolus Cytoplasm Nuclear Matrix PML Body Pronucleus	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Chromosome Cytoplasm Golgi Apparatus Centrosome Actin Cytoskeleton PML Body
	Molecular Function	Bubble DNA Binding P53 Binding Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Helicase Activity Four-way Junction Helicase Activity ATPase Activity Annealing Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Strand Renaturation DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To X-ray Replication Fork Processing DNA Duplex Unwinding Positive Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Recombination Negative Regulation Of Mitotic Recombination Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Replication Fork Protection Regulation Of Binding Protein Oligomerization Negative Regulation Of Cell Division Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation
Pathways		Meiotic recombination
Drugs
Diseases
GWAS			Iron status biomarkers ( 19084217)
Protein-Protein Interactions		33 interactors: ATM ATR ATRX BRIP1 CASP3 CHAF1A CHEK1 FANCD2 FEN1 MCRS1 MIB1 MLH1 MX1 PSMD3 RAD51 RAD51D RNF8 RPA1 SMC1A SUMO1 SUMO2 SUMO3 SYN1 TERF1 TERF2 TOP3A TOPBP1 TP53 TP53BP1 TRIM49 UBE2I UPF2 WRN	19 interactors: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CHEK1 CLSTN1 E2F1 PML POLE PPP1CC RAD9A TBC1D4 TCFL5 TICRR TOP2B UBR5 ZBTB17
Entrez ID		641	11073
HPRD ID		05211	09678
Ensembl ID		ENSG00000197299	ENSG00000163781
Uniprot IDs		P54132	A0AV47 A7E2X7 Q05BV8 Q92547
PDB IDs		2KV2 2RRD	1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Repair Cellular Response To Stress Double-strand Break Repair Chromosome Organization DNA Recombination Cell Cycle Response To Stress Cell Cycle Process Organelle Organization Response To Radiation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Aging Telomere Maintenance Nitrogen Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of DNA Metabolic Process Meiotic Nuclear Division Meiotic Cell Cycle Cell Cycle Checkpoint Response To Abiotic Stimulus Replicative Senescence Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of DNA Replication Response To Gamma Radiation Cellular Response To Ionizing Radiation Regulation Of DNA Replication Response To UV Cellular Response To Radiation Mitotic Cell Cycle Protein Sumoylation Metabolic Process DNA Damage Checkpoint DNA Conformation Change Response To Stimulus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Aging Regulation Of Cell Cycle Process	Mitotic Cell Cycle Cell Cycle Checkpoint Cellular Response To Stress Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint DNA Repair Regulation Of Response To DNA Damage Stimulus Response To Radiation DNA Metabolic Process Mitotic Cell Cycle Checkpoint Cellular Nitrogen Compound Metabolic Process Response To Stress Negative Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Induced Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Response To Abiotic Stimulus DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Regulation Of Organelle Organization Cellular Macromolecule Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Cellular Response To Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Biosynthetic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction G2 DNA Damage Checkpoint Cellular Response To Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Apoptotic Process
Tagcloud ?		bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol	abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv
Tagcloud (Difference) ?		bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol	abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv
Tagcloud (Intersection) ?