CCR8 and CCL4

Number of citations of the paper that reports this interaction (PMID 9521068)
17

Data Source:
HPRD (in vivo, in vitro)

		CCR8	CCL4
Gene Name		chemokine (C-C motif) receptor 8	chemokine (C-C motif) ligand 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding
	Biological Process	Chemotaxis Immune Response Cell Adhesion G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway	Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Negative Regulation By Host Of Viral Transcription Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CCL1 CCL16 CCL17 CCL4 TPST1 TPST2	8 interactors: ACKR2 CCL3 CCR1 CCR3 CCR5 CCR8 CXCL8 SLC30A2
Entrez ID		1237	6351
HPRD ID		03497	01657
Ensembl ID		ENSG00000179934
Uniprot IDs		P51685	P13236
PDB IDs			1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Peptidyl-tyrosine Sulfation Protein Sulfation Inflammatory Response Sulfation Chemotaxis Cell Migration Cell Motility Locomotion Immune Response Defense Response Movement Of Cell Or Subcellular Component Response To External Stimulus Prevention Of Polyspermy Immune System Process Cell-cell Signaling Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation By Host Of Viral Transcription Sulfur Compound Metabolic Process Fusion Of Sperm To Egg Plasma Membrane Plasma Membrane Fusion Egg Activation Response To Stress Negative Regulation Of Viral Transcription Negative Regulation Of Myoblast Differentiation Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Regulation Of Lymphocyte Migration Interaction With Symbiont Regulation Of Myoblast Differentiation Regulation Of Calcium-mediated Signaling Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Leukocyte Chemotaxis	Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Cytokine-mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Locomotion Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Leukocyte Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Response To External Stimulus Cellular Ion Homeostasis Cellular Response To Organic Substance Cell Chemotaxis Metal Ion Homeostasis Cellular Chemical Homeostasis G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Leukocyte Migration Immune Response Defense Response Cellular Homeostasis Response To Organic Substance Positive Regulation Of Leukocyte Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Leukocyte Migration Chemical Homeostasis Calcium-mediated Signaling Cell Surface Receptor Signaling Pathway Sarcoplasmic Reticulum Calcium Ion Transport Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Dendritic Cell Chemotaxis Regulation Of Chemotaxis Second-messenger-mediated Signaling Immune System Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Neutrophil Activation Regulation Of Ion Homeostasis Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Response To Cholesterol Regulation Of Behavior Dendritic Cell Migration
Tagcloud ?		3p21 bimodal call chemokine chemokines chemotaxis chemr1 ckr cloning cxcr1 cxcr4 faint freshly l1 leukocytes lymphocytes mobilization nomenclature phytohemagglutinin responsiveness served stably stromal subnanomolar ter1 termed transfected unusual	acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript
Tagcloud (Difference) ?		3p21 bimodal call chemokine chemokines chemotaxis chemr1 ckr cloning cxcr1 cxcr4 faint freshly l1 leukocytes lymphocytes mobilization nomenclature phytohemagglutinin responsiveness served stably stromal subnanomolar ter1 termed transfected unusual	acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript
Tagcloud (Intersection) ?