RPS6KB1 and NEK6

Number of citations of the paper that reports this interaction (PMID 11516946)
14

Data Source:
HPRD (in vivo, in vitro)

		RPS6KB1	NEK6
Gene Name		ribosomal protein S6 kinase, 70kDa, polypeptide 1	NIMA-related kinase 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Surface Cell Junction Neuron Projection Synapse Perinuclear Region Of Cytoplasm	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Cytosol Microtubule Nuclear Speck
	Molecular Function	Protein Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Peptide Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Skeletal Muscle Contraction Protein Phosphorylation Apoptotic Process Signal Transduction Germ Cell Development Aging Response To Nutrient Long-term Memory Insulin Receptor Signaling Pathway Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Toxic Substance Response To Glucose Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration TOR Signaling Response To Lipopolysaccharide Response To Testosterone Response To Glucagon Response To Tumor Necrosis Factor Response To Drug Negative Regulation Of Apoptotic Process Response To Leucine Protein Kinase B Signaling Response To Ethanol Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Smooth Muscle Cell Proliferation Response To Glucocorticoid Cellular Response To Growth Factor Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Mitotic Cell Cycle Cytokinesis Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Signal Transduction Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition G2 DNA Damage Checkpoint Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Regulation Of Cellular Senescence
Pathways		Insulin receptor signalling cascade IRS-mediated signalling mTOR signalling S6K1 signalling S6K1-mediated signalling IRS-related events mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling S6K1 signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PKB-mediated events PI3K Cascade PI3K Cascade Signaling by Insulin receptor	Mitotic Prophase Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown Nuclear Pore Complex (NPC) Disassembly Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661)	Cognitive performance ( 20125193)
Protein-Protein Interactions		54 interactors: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DPPA4 EEF2K EIF4B EIF4EBP1 EP300 GDI2P1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MLST8 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RICTOR RPS6 RPTOR SRC STK11 SYK TERT TRAF4 URI1 XPO1	42 interactors: AES ANKRA2 ARHGAP33 ARRB1 ATF4 CCDC36 CCDC85B CDC42 CDK7 CIR1 ERCC6L2 FAM208B HSD17B14 IKZF1 IKZF3 INCA1 KCTD5 KRT31 KRT40 LNX1 LZTS2 NECAB2 NEK9 PAK6 PHF1 PIN1 PRAM1 PRDX3 PTN RBBP6 RPS6KB1 RPS7 SGK1 SMAD4 SMURF2 TCF4 TGFBR1 TNK2 TRIM23 TRIM27 TRIP4 XIAP
Entrez ID		6198	10783
HPRD ID		10202	05348
Ensembl ID		ENSG00000108443	ENSG00000119408
Uniprot IDs		B2R779 B4DLT4 B4DTG1 F6UYM1 P23443 Q7Z721	Q9HC98
PDB IDs		3A60 3A61 3A62 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Peptide Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Peptide Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Stimulus Positive Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Signal Transduction Regulation Of Signaling Innate Immune Response Intracellular Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Communication Immune Response Positive Regulation Of Protein Modification Process Regulation Of Kinase Activity Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process T Cell Costimulation Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway	Regulation Of Metabolic Process Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process RNA Biosynthetic Process Regulation Of Catalytic Activity Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Binding Regulation Of Phosphorylation Negative Regulation Of Gene Expression Regulation Of Protein Binding Regulation Of Protein Phosphorylation Regulation Of Growth Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Signal Transduction Response To Stress Cellular Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Ubiquitination Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation RNA Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Signaling Negative Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Endothelial Cell Activation Wnt Signaling Pathway
Tagcloud ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk	23a abolishes attenuated attenuates berberine biogenesis chromatin detecting g2 gadd45alpha hcc hepatocellular immunoblotting mature mediate mediating microrna mir monitored onto p21 precursor prediction reveals suppress suppressive transcript upon validation
Tagcloud (Difference) ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk	23a abolishes attenuated attenuates berberine biogenesis chromatin detecting g2 gadd45alpha hcc hepatocellular immunoblotting mature mediate mediating microrna mir monitored onto p21 precursor prediction reveals suppress suppressive transcript upon validation
Tagcloud (Intersection) ?