RPS6KB1 and CDC42

Number of citations of the paper that reports this interaction (PMID 11438723)
10

Data Source:
HPRD (in vitro)

		RPS6KB1	CDC42
Gene Name		ribosomal protein S6 kinase, 70kDa, polypeptide 1	cell division cycle 42
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Surface Cell Junction Neuron Projection Synapse Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Secretory Granule Filopodium Midbody Leading Edge Membrane Cytoplasmic Ribonucleoprotein Granule Neuron Projection Neuronal Cell Body Apical Part Of Cell Spindle Midzone Extracellular Vesicular Exosome Mitotic Spindle
	Molecular Function	Protein Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Peptide Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding GTP-dependent Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Thioesterase Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Skeletal Muscle Contraction Protein Phosphorylation Apoptotic Process Signal Transduction Germ Cell Development Aging Response To Nutrient Long-term Memory Insulin Receptor Signaling Pathway Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Toxic Substance Response To Glucose Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration TOR Signaling Response To Lipopolysaccharide Response To Testosterone Response To Glucagon Response To Tumor Necrosis Factor Response To Drug Negative Regulation Of Apoptotic Process Response To Leucine Protein Kinase B Signaling Response To Ethanol Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Smooth Muscle Cell Proliferation Response To Glucocorticoid Cellular Response To Growth Factor Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Sprouting Angiogenesis Cardiac Conduction System Development Keratinocyte Development Golgi Organization Regulation Of Mitotic Nuclear Division Nuclear Migration Establishment Or Maintenance Of Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Substantia Nigra Development Actin Cytoskeleton Organization Macrophage Differentiation Hair Follicle Morphogenesis Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Negative Regulation Of Protein Complex Assembly Keratinization Regulation Of Protein Stability Positive Regulation Of Cytokinesis Positive Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Organization Cellular Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Multicellular Organism Growth Dendritic Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Muscle Cell Differentiation Regulation Of Protein Heterodimerization Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of DNA Replication Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Filopodium Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Metalloenzyme Activity Neuron Fate Determination Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Muscle Cell Differentiation Regulation Of Filopodium Assembly Establishment Of Golgi Localization Positive Regulation Of Synapse Structural Plasticity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Heart Contraction Canonical Wnt Signaling Pathway Submandibular Salivary Gland Formation Epithelial-mesenchymal Cell Signaling Hair Follicle Placode Formation Positive Regulation Of Hair Follicle Cell Proliferation Organelle Transport Along Microtubule Actin Filament Branching Epithelial Cell-cell Adhesion Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Insulin receptor signalling cascade IRS-mediated signalling mTOR signalling S6K1 signalling S6K1-mediated signalling IRS-related events mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling S6K1 signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PKB-mediated events PI3K Cascade PI3K Cascade Signaling by Insulin receptor	Signaling by GPCR Costimulation by the CD28 family Axon guidance DCC mediated attractive signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Inactivation of Cdc42 and Rac Rho GTPase cycle EPHB-mediated forward signaling EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Sema4D induced cell migration and growth-cone collapse Regulation of actin dynamics for phagocytic cup formation Innate Immune System EGFR downregulation CDO in myogenesis Semaphorin interactions CD28 co-stimulation Signaling by Ligand-Responsive EGFR Variants in Cancer Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway Signaling by EGFR GPCR downstream signaling Myogenesis Signaling by VEGF Signaling by Rho GTPases Signaling by EGFR in Cancer GPVI-mediated activation cascade Platelet activation, signaling and aggregation Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661)	Immune response to smallpox vaccine (IL-6) ( 22610502)
Protein-Protein Interactions		54 interactors: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DPPA4 EEF2K EIF4B EIF4EBP1 EP300 GDI2P1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MLST8 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RICTOR RPS6 RPTOR SRC STK11 SYK TERT TRAF4 URI1 XPO1	144 interactors: A2M ACTR3 AHSG ANXA2 APOH ARHGAP1 ARHGAP10 ARHGAP17 ARHGAP26 ARHGAP27 ARHGAP29 ARHGAP31 ARHGAP32 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF11 ARHGEF25 ARHGEF6 ARHGEF7 ARRB1 ARRB2 BAIAP2 BCR BNIP2 BNIPL C14orf1 CASP3 CASP7 CBLL1 CDC42BPA CDC42BPB CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE1 CDC42SE2 CDH1 CDKN1A CFHR4 CNTNAP1 COX1 CPN1 CSN2 CSPG4 DEF6 DIAPH2 DIAPH3 DOCK7 DOCK8 DOCK9 EEF1G EIF2AK2 ERRFI1 ETFA FGD1 FGD3 FLNA FMNL2 FNBP1 GDI1 GOPC GRB2 HERC2 IQGAP1 IQGAP2 ITSN1 KAT5 KIAA2026 KTN1 LCK LGALS1 LRIF1 MAP3K10 MAP3K11 MAP3K4 MARK4 MCF2 MCF2L MCM3AP METAP2 MUC12 MYO6 MYO9A NCF2 NEK6 OCRL OPHN1 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PARD3 PARD6A PARD6B PARD6G PDE6D PGGT1B PIK3R1 PLD1 PLEKHG2 PRKCA PRKCG PRKCI PRKCZ RAC1 RAC2 RAP1GDS1 RHOJ RIOK3 RPL22 RPL23 RPS6KB1 S100A9 SH3D19 SRGAP1 SSX2IP ST13 STAU1 SYNE1 TBC1D3F TNK2 TP53 TRAF2 TRIP10 UBR1 UNC119 USP6 VAV1 VRK2 WAS WASF1 WASF2 WASL WIPF1 ZNF175 ZNF234 ZNF420
Entrez ID		6198	998
HPRD ID		10202	00309
Ensembl ID		ENSG00000108443	ENSG00000070831
Uniprot IDs		B2R779 B4DLT4 B4DTG1 F6UYM1 P23443 Q7Z721	B4E1U9 E7ETU3 P60953
PDB IDs		3A60 3A61 3A62 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46	1A4R 1AJE 1AM4 1AN0 1CEE 1CF4 1DOA 1E0A 1EES 1GRN 1GZS 1KI1 1KZ7 1KZG 1NF3 2ASE 2DFK 2KB0 2NGR 2ODB 2QRZ 2WM9 2WMN 2WMO 3GCG 3QBV 3VHL 4DID 4ITR
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Peptide Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Peptide Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Stimulus Positive Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Signal Transduction Regulation Of Signaling Innate Immune Response Intracellular Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Communication Immune Response Positive Regulation Of Protein Modification Process Regulation Of Kinase Activity Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process T Cell Costimulation Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway	Regulation Of Catalytic Activity Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Metabolic Process Signaling Regulation Of Rho Protein Signal Transduction Regulation Of Rho GTPase Activity Cell Communication Positive Regulation Of Ras GTPase Activity Cytoskeleton Organization Cellular Response To Stimulus Regulation Of Ras Protein Signal Transduction Response To Stimulus Regulation Of Ras GTPase Activity Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Apoptotic Process Cell Death Death Neurotrophin Signaling Pathway Programmed Cell Death Rho Protein Signal Transduction Movement Of Cell Or Subcellular Component Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Death Response To Growth Factor Organelle Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Endocytosis Locomotion Positive Regulation Of Apoptotic Process
Tagcloud ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk	abolished adapter adjacent autophosphorylation coprecipitate coprecipitation detailed explained fragment gtpase hck homology identity modeling mutational nak nck nef p21 pak paks plasmon resonance sh3 src subset termed threonine uncertain
Tagcloud (Difference) ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk	abolished adapter adjacent autophosphorylation coprecipitate coprecipitation detailed explained fragment gtpase hck homology identity modeling mutational nak nck nef p21 pak paks plasmon resonance sh3 src subset termed threonine uncertain
Tagcloud (Intersection) ?