RPS6KB1 and EIF4B

Number of citations of the paper that reports this interaction (PMID 16763566)
75

Data Source:
HPRD (in vivo, in vitro)

		RPS6KB1	EIF4B
Gene Name		ribosomal protein S6 kinase, 70kDa, polypeptide 1	eukaryotic translation initiation factor 4B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Surface Cell Junction Neuron Projection Synapse Perinuclear Region Of Cytoplasm	Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Protein Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Peptide Binding	Nucleotide Binding RNA Binding Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Skeletal Muscle Contraction Protein Phosphorylation Apoptotic Process Signal Transduction Germ Cell Development Aging Response To Nutrient Long-term Memory Insulin Receptor Signaling Pathway Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Toxic Substance Response To Glucose Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration TOR Signaling Response To Lipopolysaccharide Response To Testosterone Response To Glucagon Response To Tumor Necrosis Factor Response To Drug Negative Regulation Of Apoptotic Process Response To Leucine Protein Kinase B Signaling Response To Ethanol Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Smooth Muscle Cell Proliferation Response To Glucocorticoid Cellular Response To Growth Factor Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Cellular Protein Metabolic Process
Pathways		Insulin receptor signalling cascade IRS-mediated signalling mTOR signalling S6K1 signalling S6K1-mediated signalling IRS-related events mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling S6K1 signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PKB-mediated events PI3K Cascade PI3K Cascade Signaling by Insulin receptor	Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Deadenylation of mRNA Translation S6K1 signalling IRS-related events L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling mTORC1-mediated signalling Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661)	Prostate cancer ( 21743057)
Protein-Protein Interactions		54 interactors: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DPPA4 EEF2K EIF4B EIF4EBP1 EP300 GDI2P1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MLST8 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RICTOR RPS6 RPTOR SRC STK11 SYK TERT TRAF4 URI1 XPO1	12 interactors: ACD CASP3 CSNK2A1 EIF3A EIF4E PABPC1 PAK2 POT1 RPS6KB1 SFN TERF1 TINF2
Entrez ID		6198	1975
HPRD ID		10202	04892
Ensembl ID		ENSG00000108443	ENSG00000063046
Uniprot IDs		B2R779 B4DLT4 B4DTG1 F6UYM1 P23443 Q7Z721	B4DS13 E7EX17 P23588
PDB IDs		3A60 3A61 3A62 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46	1WI8 2J76
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Peptide Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Peptide Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Stimulus Positive Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Signal Transduction Regulation Of Signaling Innate Immune Response Intracellular Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Communication Immune Response Positive Regulation Of Protein Modification Process Regulation Of Kinase Activity Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process T Cell Costimulation Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomere Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of DNA Replication Telomere Maintenance Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of DNA Metabolic Process Negative Regulation Of Transferase Activity Regulation Of DNA Replication Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Organelle Organization Regulation Of Cell Cycle Regulation Of Cysteine-type Endopeptidase Activity Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Regulation Of Translation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Regulation Of Proteolysis Positive Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Mitotic Cell Cycle Negative Regulation Of Proteolysis Homeostatic Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Regulation Of Peptidase Activity Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process
Tagcloud ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk	43s 48s 4a 4f assumed cap capped codon coherent description dissociate eif1 eif1a eif4a eif4f exclusively incubated individually initiation mediate messenger preinitiation reach ribosomal ribosomes synergistically unable weakly
Tagcloud (Difference) ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk	43s 48s 4a 4f assumed cap capped codon coherent description dissociate eif1 eif1a eif4a eif4f exclusively incubated individually initiation mediate messenger preinitiation reach ribosomal ribosomes synergistically unable weakly
Tagcloud (Intersection) ?