RPGR and IFT88

Number of citations of the paper that reports this interaction (PMID 16043481)
39

Data Source:
HPRD (in vivo)

		RPGR	IFT88
Gene Name		retinitis pigmentosa GTPase regulator	intraflagellar transport 88
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Golgi Apparatus Centrosome Ciliary Basal Body Sperm Flagellum	Acrosomal Membrane Centriole Cilium Intraciliary Transport Particle B Motile Primary Cilium Motile Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Apical Part Of Cell Kinocilium Primary Cilium Axonemal Basal Plate Ciliary Tip Ciliary Base
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Poly(A) RNA Binding	Kinesin Binding
	Biological Process	Intracellular Protein Transport Visual Perception Intraciliary Transport Cilium Assembly Eye Photoreceptor Cell Development Positive Regulation Of GTPase Activity Response To Stimulus	Eye Development Kidney Development Liver Development Epithelial Cell Morphogenesis Organelle Organization Notch Signaling Pathway Smoothened Signaling Pathway Sperm Axoneme Assembly Spermatid Nucleus Elongation Determination Of Left/right Symmetry Protein Localization Epidermis Development Regulation Of Smoothened Signaling Pathway Anterior/posterior Pattern Specification Spinal Cord Dorsal/ventral Patterning Telencephalon Development Pancreas Development Cytoplasmic Microtubule Organization Response To Fluid Shear Stress Epidermal Stem Cell Homeostasis Regulation Of Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Fat Cell Differentiation Forebrain Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Cardiac Muscle Cell Differentiation Palate Development Inner Ear Receptor Stereocilium Organization Cilium Morphogenesis Cardiac Septum Morphogenesis Lung Vasculature Development Heart Formation Regulation Of Protein Processing Cochlea Development Regulation Of Cilium Assembly Regulation Of Autophagic Vacuole Assembly
Pathways			Organelle biogenesis and maintenance Hedgehog 'off' state Signaling by Hedgehog Assembly of the primary cilium Intraflagellar transport
Drugs
Diseases
GWAS			Dental caries ( 23064961) Schizophrenia, bipolar disorder and depression (combined) ( 20713499)
Protein-Protein Interactions		13 interactors: DCTN1 DCTN2 IFT88 KIF3A KIFAP3 NPM1 PDE6D RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE	2 interactors: PRRC2A RPGR
Entrez ID		6103	8100
HPRD ID		02425	09000
Ensembl ID		ENSG00000156313	ENSG00000032742
Uniprot IDs		Q92834	B3KX42 F5H6C2 Q13099
PDB IDs		4JHN 4JHP
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Epidermal Stem Cell Homeostasis Cell Cycle Process G2/M Transition Of Mitotic Cell Cycle Spindle Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Spindle Organization Cell Cycle Negative Regulation Of DNA Endoreduplication Establishment Of Vesicle Localization Plus-end-directed Vesicle Transport Along Microtubule Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of DNA Endoreduplication Antigen Processing And Presentation Cytoskeleton Organization Mitotic Sister Chromatid Cohesion Mitotic Nuclear Division Establishment Of Organelle Localization Establishment Of Localization In Cell Microtubule-based Transport Inner Ear Receptor Stereocilium Organization Cytoskeleton-dependent Intracellular Transport Organelle Localization Intracellular Transport Sister Chromatid Cohesion Cellular Localization Response To Stress Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Vesicle Transport Along Microtubule Cytoplasmic Microtubule Organization Meiotic Cell Cycle Melanosome Localization Inner Ear Receptor Cell Development Negative Regulation Of DNA Replication Organelle Transport Along Microtubule Cellular Pigmentation Inner Ear Receptor Cell Differentiation Microtubule-based Movement Regulation Of Endoribonuclease Activity	Intraciliary Transport Eye Photoreceptor Cell Development Photoreceptor Cell Development Eye Photoreceptor Cell Differentiation
Tagcloud ?		acuity carriers decade erg examinations eye fields genotypically gtpase hemi identifiable kindred lys756del2aaag minimally oct ophthalmic orf15 perception phenotypically pigmentosa plottable profound puerto retinitis rican spearman teens visual	ag1478 amiloride cilia collecting duct efflux egf erbb1 erbb3 erbb4 exchangers exerts hypomorph isobutyl mek mia mitogenic mrnas nhe nhes orpk pd98059 pkd polycystic pronounced proton severely stunted tg737
Tagcloud (Difference) ?		acuity carriers decade erg examinations eye fields genotypically gtpase hemi identifiable kindred lys756del2aaag minimally oct ophthalmic orf15 perception phenotypically pigmentosa plottable profound puerto retinitis rican spearman teens visual	ag1478 amiloride cilia collecting duct efflux egf erbb1 erbb3 erbb4 exchangers exerts hypomorph isobutyl mek mia mitogenic mrnas nhe nhes orpk pd98059 pkd polycystic pronounced proton severely stunted tg737
Tagcloud (Intersection) ?