EDA2R and C1QB

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EDA2R	C1QB
Gene Name		ectodysplasin A2 receptor	complement component 1, q subcomponent, B chain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Epidermis Development Ectodermal Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Complement Activation Complement Activation, Classical Pathway Innate Immune Response Inner Ear Development
Pathways			Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS		Male-pattern baldness ( 22032556)
Protein-Protein Interactions		7 interactors: C1QB CASP8 CEBPE EDA FADD TRAF3 TRAF6	10 interactors: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA
Entrez ID		60401	713
HPRD ID		02230	00394
Ensembl ID		ENSG00000131080	ENSG00000173369
Uniprot IDs		B2RBZ9 E7EUS4 Q9HAV5	P02746
PDB IDs			1PK6 2JG8 2JG9 2WNU 2WNV
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Immune System Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Immune Response TRAIL-activated Apoptotic Signaling Pathway Defense Response Positive Regulation Of Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Innate Immune Response Innate Immune Response Positive Regulation Of Myeloid Cell Differentiation Leukocyte Differentiation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Myeloid Leukocyte Differentiation Myeloid Leukocyte Differentiation Positive Regulation Of Macrophage Differentiation Immune Response-regulating Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Necrotic Cell Death Regulation Of Necroptotic Process Regulation Of Immune System Process Macrophage Differentiation Tube Formation Regulation Of Myeloid Cell Differentiation Hemopoiesis Regulation Of Necrotic Cell Death Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Immune System Development Organ Development Response To Other Organism Response To Biotic Stimulus Myeloid Cell Differentiation Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stress Regulation Of T Cell Apoptotic Process Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process	Defense Response Immune Response Innate Immune Response Response To Fungus Humoral Immune Response Positive Regulation Of Immune Response Immune System Process Response To Stress Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Response To Stimulus Protein Activation Cascade Positive Regulation Of Focal Adhesion Assembly Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Positive Regulation Of Adherens Junction Organization Defense Response To Fungus Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Other Organism Leukocyte Mediated Immunity Adaptive Immune Response Response To Biotic Stimulus Regulation Of Focal Adhesion Assembly Positive Regulation Of Cell-matrix Adhesion Regulation Of Cell Junction Assembly ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Acetaldehyde Metabolic Process Cellular Response To Tumor Necrosis Factor ERBB2 Signaling Pathway Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Positive Regulation Of Schwann Cell Differentiation Heme Export Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Exo-alpha-sialidase Activity Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Schwann Cell Differentiation Negative Regulation Of Lamellipodium Assembly Response To Tumor Necrosis Factor Negative Regulation Of Endothelial Cell Chemotaxis Response To Cobalamin Defense Response To Virus Regulation Of Locomotion
Tagcloud ?		admixture africans await breed ce compositionally deflate edar fst gujarati hemizygous herc2 homozygosity initio lct maasai mathematically organised phylogeography pigmentation prioritised proxy relatedness remodeler runs scmh1 slc24a5 sliding visualise	antioxidative atf3 atf4 atf5 axonal believe c1qa c1qc c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3
Tagcloud (Difference) ?		admixture africans await breed ce compositionally deflate edar fst gujarati hemizygous herc2 homozygosity initio lct maasai mathematically organised phylogeography pigmentation prioritised proxy relatedness remodeler runs scmh1 slc24a5 sliding visualise	antioxidative atf3 atf4 atf5 axonal believe c1qa c1qc c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3
Tagcloud (Intersection) ?