C1QB and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
HPRD (two hybrid)

		C1QB	MYOC
Gene Name		complement component 1, q subcomponent, B chain	myocilin, trabecular meshwork inducible glucocorticoid response
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Vesicular Exosome Blood Microparticle	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Homodimerization Activity	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Complement Activation Complement Activation, Classical Pathway Innate Immune Response Inner Ear Development	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		713	4653
HPRD ID		00394	03387
Ensembl ID		ENSG00000173369	ENSG00000034971
Uniprot IDs		P02746	Q99972
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV
Enriched GO Terms of Interacting Partners?		Defense Response Immune Response Innate Immune Response Response To Fungus Humoral Immune Response Positive Regulation Of Immune Response Immune System Process Response To Stress Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Response To Stimulus Protein Activation Cascade Positive Regulation Of Focal Adhesion Assembly Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Positive Regulation Of Adherens Junction Organization Defense Response To Fungus Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Other Organism Leukocyte Mediated Immunity Adaptive Immune Response Response To Biotic Stimulus Regulation Of Focal Adhesion Assembly Positive Regulation Of Cell-matrix Adhesion Regulation Of Cell Junction Assembly ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Acetaldehyde Metabolic Process Cellular Response To Tumor Necrosis Factor ERBB2 Signaling Pathway Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Positive Regulation Of Schwann Cell Differentiation Heme Export Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Exo-alpha-sialidase Activity Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Schwann Cell Differentiation Negative Regulation Of Lamellipodium Assembly Response To Tumor Necrosis Factor Negative Regulation Of Endothelial Cell Chemotaxis Response To Cobalamin Defense Response To Virus Regulation Of Locomotion	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		antioxidative atf3 atf4 atf5 axonal believe c1qa c1qc c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		antioxidative atf3 atf4 atf5 axonal believe c1qa c1qc c57bl chac1 chop concurrently crush defense egr1 ganglion hmox1 onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glycerol hubs hydrophilic inherited mapped movements myocilin olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?		glaucoma ocular