RXFP1 and RLN3

Number of citations of the paper that reports this interaction (PMID 14522968)
29

Data Source:
HPRD (in vitro, in vivo)

		RXFP1	RLN3
Gene Name		relaxin/insulin-like family peptide receptor 1	relaxin 3
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Metal Ion Binding	G-protein Coupled Receptor Binding Hormone Activity Protein Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: RLN1 RLN2 RLN3	3 interactors: RXFP1 RXFP3 RXFP4
Entrez ID		59350	117579
HPRD ID		05975	06031
Ensembl ID		ENSG00000171509
Uniprot IDs		B3KV27 B4DGP2 Q59H16 Q9HBX9	Q8WXF3
PDB IDs		2JM4 2M7P	2FHW 2K1V
Enriched GO Terms of Interacting Partners?		Female Pregnancy Reproductive Process	G-protein Coupled Receptor Signaling Pathway Angiotensin-activated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Parturition Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytokinesis Regulation Of Cytokinesis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		bioactive birth boars borne esr1 fed gata insl3 lactocrine leydig libitum neonatal nursed p450 p450scc pan pnd porcine proliferating reflected relaxin replacer sertoli steroidogenic testes testicular vegfa whereby	accompanied activate cardiogenesis cardiomyocyte cardiomyocytes certain delivery dynamic exogenous heart injury jak1 lost program purification regenerate regeneration restricted ribosome rln3a rnas secreted spared stat3 transgenic translating trauma vertebrates zebrafish
Tagcloud (Difference) ?		bioactive birth boars borne esr1 fed gata insl3 lactocrine leydig libitum neonatal nursed p450 p450scc pan pnd porcine proliferating reflected relaxin replacer sertoli steroidogenic testes testicular vegfa whereby	accompanied activate cardiogenesis cardiomyocyte cardiomyocytes certain delivery dynamic exogenous heart injury jak1 lost program purification regenerate regeneration restricted ribosome rln3a rnas secreted spared stat3 transgenic translating trauma vertebrates zebrafish
Tagcloud (Intersection) ?