RLN3 and RXFP1

Number of citations of the paper that reports this interaction (PMID 12506116)
29

Data Source:
HPRD (in vitro, in vivo)

		RLN3	RXFP1
Gene Name		relaxin 3	relaxin/insulin-like family peptide receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region	Plasma Membrane Integral Component Of Membrane
	Molecular Function	G-protein Coupled Receptor Binding Hormone Activity Protein Binding	G-protein Coupled Receptor Activity Protein Binding Metal Ion Binding
	Biological Process		G-protein Coupled Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: RXFP1 RXFP3 RXFP4	3 interactors: RLN1 RLN2 RLN3
Entrez ID		117579	59350
HPRD ID		06031	05975
Ensembl ID			ENSG00000171509
Uniprot IDs		Q8WXF3	B3KV27 B4DGP2 Q59H16 Q9HBX9
PDB IDs		2FHW 2K1V	2JM4 2M7P
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Angiotensin-activated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Parturition Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytokinesis Regulation Of Cytokinesis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway	Female Pregnancy Reproductive Process
Tagcloud ?		accompanied activate cardiogenesis cardiomyocyte cardiomyocytes certain delivery dynamic exogenous heart injury jak1 lost program purification regenerate regeneration restricted ribosome rln3a rnas secreted spared stat3 transgenic translating trauma vertebrates zebrafish	bioactive birth boars borne esr1 fed gata insl3 lactocrine leydig libitum neonatal nursed p450 p450scc pan pnd porcine proliferating reflected relaxin replacer sertoli steroidogenic testes testicular vegfa whereby
Tagcloud (Difference) ?		accompanied activate cardiogenesis cardiomyocyte cardiomyocytes certain delivery dynamic exogenous heart injury jak1 lost program purification regenerate regeneration restricted ribosome rln3a rnas secreted spared stat3 transgenic translating trauma vertebrates zebrafish	bioactive birth boars borne esr1 fed gata insl3 lactocrine leydig libitum neonatal nursed p450 p450scc pan pnd porcine proliferating reflected relaxin replacer sertoli steroidogenic testes testicular vegfa whereby
Tagcloud (Intersection) ?