HRH4 and GNAO1

Number of citations of the paper that reports this interaction (PMID 10973974)
48

Data Source:
HPRD (in vivo)

		HRH4	GNAO1
Gene Name		histamine receptor H4	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection
	Molecular Function	Histamine Receptor Activity	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Biological_process Regulation Of MAPK Cascade	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Histamine receptors	Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling
Drugs		Clozapine Histamine Phosphate
Diseases
GWAS		Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		4 interactors: CCL16 GNA15 GNAI1 GNAO1	34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR
Entrez ID		59340	2775
HPRD ID		06004	00757
Ensembl ID		ENSG00000134489	ENSG00000087258
Uniprot IDs		B2KJ49 Q9H3N8	B3KP89 P09471 Q6AWC5 Q8N6I9
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dopamine Receptor Signaling Pathway Platelet Activation G-protein Coupled Receptor Signaling Pathway Response To Stress Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Blood Coagulation Hemostasis G-protein Coupled Acetylcholine Receptor Signaling Pathway Signaling Regulation Of Body Fluid Levels Cell Communication Wound Healing Positive Chemotaxis Cell Activation Response To Wounding Cellular Response To Stimulus Response To Morphine Negative Regulation Of Calcium Ion Transport Response To Organonitrogen Compound Cell Surface Receptor Signaling Pathway Cell-cell Signaling Activation Of Phospholipase C Activity Vesicle Fusion Positive Regulation Of Phospholipase C Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Organelle Fusion Positive Regulation Of Phospholipase Activity Response To Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Response To Ammonium Ion Negative Regulation Of Ion Transport	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell
Tagcloud ?			aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Difference) ?			aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Intersection) ?