GNAO1 and NGB

Number of citations of the paper that reports this interaction (PMID 12860983)
41

Data Source:
HPRD (in vitro)

		GNAO1	NGB
Gene Name		guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	neuroglobin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection	Mitochondrion Perikaryon
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Oxygen Transporter Activity Iron Ion Binding Oxygen Binding Heme Binding
	Biological Process	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Apoptotic Process Oxygen Transport
Pathways		Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	12 interactors: ATP1B2 C1orf94 CCDC36 FLOT1 GNAI1 GNAI2 GNAI3 GNAO1 L3MBTL3 REL TDO2 VAC14
Entrez ID		2775	58157
HPRD ID		00757	05602
Ensembl ID		ENSG00000087258	ENSG00000165553
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	A0M8W9 Q9NPG2
PDB IDs			1OJ6
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Platelet Activation Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Response To Wounding Vesicle Fusion Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Organelle Fusion Regulation Of CAMP Biosynthetic Process Cell Division Regulation Of CAMP Metabolic Process Tryptophan Catabolic Process To Acetyl-CoA G-protein Coupled Receptor Signaling Pathway Response To Stress Positive Regulation Of Potassium Ion Import Membrane Fusion Synaptic Transmission Regulation Of Catalytic Activity Positive Regulation Of Sodium Ion Export From Cell Regulation Of Ion Transport Regulation Of Heart Contraction Cell Activation Sodium Ion Export From Cell Signaling Cell Communication Methotrexate Transport Regulation Of Calcium Ion Transport Sodium Ion Export Vesicle Organization Folic Acid Transport Cellular Potassium Ion Homeostasis Tryptophan Catabolic Process To Kynurenine Response To Stimulus Metabolic Process Membrane Organization Cellular Modified Amino Acid Metabolic Process Folic Acid Metabolic Process Kynurenine Metabolic Process Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Interleukin-12 Biosynthetic Process
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	advance atrophy bladder catheterization charts cic clean cystoscopies deal detrusor doi encountered ethnicity hydronephrosis intermittent manage neurogenic november publication regularly sci sensation sphincter spinal ultrasounds urethral urological veterans void
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	advance atrophy bladder catheterization charts cic clean cystoscopies deal detrusor doi encountered ethnicity hydronephrosis intermittent manage neurogenic november publication regularly sci sensation sphincter spinal ultrasounds urethral urological veterans void
Tagcloud (Intersection) ?