GNAO1 and GPSM2

Number of citations of the paper that reports this interaction (PMID 12925752)
15

Data Source:
HPRD (in vitro)

		GNAO1	GPSM2
Gene Name		guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	G-protein signaling modulator 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection	Cytoplasm Cell Cortex Apical Part Of Cell
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Protein Binding GTPase Regulator Activity Identical Protein Binding
	Biological Process	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Establishment Of Mitotic Spindle Orientation G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Lung Epithelial Cell Differentiation
Pathways		Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	8 interactors: GLIS2 GNAI1 GNAI2 GNAI3 GNAO1 HRAS INSC NUMA1
Entrez ID		2775	29899
HPRD ID		00757	06609
Ensembl ID		ENSG00000087258	ENSG00000121957
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	P81274
PDB IDs			3SF4
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell Cycle Blood Coagulation Cell Division Hemostasis Negative Regulation Of Adenylate Cyclase Activity Regulation Of Body Fluid Levels Synaptic Transmission Negative Regulation Of Lyase Activity Wound Healing Platelet Activation Establishment Of Mitotic Spindle Orientation Negative Regulation Of CAMP Biosynthetic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Negative Regulation Of CAMP Metabolic Process Response To Wounding Lung Development Respiratory Tube Development Negative Regulation Of Nucleotide Metabolic Process Respiratory System Development Spindle Localization Lung Epithelial Cell Differentiation Lung Cell Differentiation Vesicle Fusion Cell-cell Signaling Regulation Of Adenylate Cyclase Activity Lung Epithelium Development Activation Of MAPKK Activity Regulation Of Cyclase Activity Organelle Fusion G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Establishment Of Cell Polarity Regulation Of CAMP Metabolic Process Membrane Fusion Mitotic Cell Cycle Process Cell Activation Tube Development Establishment Or Maintenance Of Cell Polarity Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Organelle Organization Positive Regulation Of Rac Protein Signal Transduction Regulation Of Calcium Ion Transport Negative Regulation Of Catalytic Activity Positive Regulation Of MiRNA Metabolic Process Response To Organonitrogen Compound
Tagcloud ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	camk1 centriole dkk1 enah endosome geo inference kcnq3 kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Difference) ?		aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53	camk1 centriole dkk1 enah endosome geo inference kcnq3 kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Intersection) ?