HRH4 and CCL16

Number of citations of the paper that reports this interaction (PMID 15265943)
6

Data Source:
HPRD (in vivo)

		HRH4	CCL16
Gene Name		histamine receptor H4	chemokine (C-C motif) ligand 16
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Histamine Receptor Activity	Chemokine Activity Chemoattractant Activity
	Biological Process	Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Biological_process Regulation Of MAPK Cascade	Chemotaxis Inflammatory Response Immune Response Cell Communication Cell-cell Signaling Positive Chemotaxis Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Histamine receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Clozapine Histamine Phosphate
Diseases
GWAS		Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		4 interactors: CCL16 GNA15 GNAI1 GNAO1	4 interactors: CCR1 CCR5 CCR8 HRH4
Entrez ID		59340	6360
HPRD ID		06004	03233
Ensembl ID		ENSG00000134489	ENSG00000161573
Uniprot IDs		B2KJ49 Q9H3N8	O15467
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dopamine Receptor Signaling Pathway Platelet Activation G-protein Coupled Receptor Signaling Pathway Response To Stress Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Blood Coagulation Hemostasis G-protein Coupled Acetylcholine Receptor Signaling Pathway Signaling Regulation Of Body Fluid Levels Cell Communication Wound Healing Positive Chemotaxis Cell Activation Response To Wounding Cellular Response To Stimulus Response To Morphine Negative Regulation Of Calcium Ion Transport Response To Organonitrogen Compound Cell Surface Receptor Signaling Pathway Cell-cell Signaling Activation Of Phospholipase C Activity Vesicle Fusion Positive Regulation Of Phospholipase C Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Organelle Fusion Positive Regulation Of Phospholipase Activity Response To Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Response To Ammonium Ion Negative Regulation Of Ion Transport	Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Chemokine-mediated Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Cellular Homeostasis Chemical Homeostasis Dendritic Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Dendritic Cell Migration Homeostatic Process Inflammatory Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Leukocyte Chemotaxis Cell Chemotaxis Cell Surface Receptor Signaling Pathway Leukocyte Migration Locomotion Immune Response Defense Response Calcium Ion Transport Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To External Stimulus Positive Regulation Of Monocyte Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Organic Substance Regulation Of Monocyte Chemotaxis Signal Transduction Immune System Process Signaling Negative Regulation Of Bone Mineralization Cell Communication Negative Regulation Of Biomineral Tissue Development Response To Cholesterol Regulation Of MAPK Cascade Response To Organic Substance Positive Regulation Of Osteoclast Differentiation Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Stimulus Regulation Of Sequestering Of Calcium Ion Cell Migration
Tagcloud ?			17f 28a 6ckine ccl13 ccl14 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1
Tagcloud (Difference) ?			17f 28a 6ckine ccl13 ccl14 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1
Tagcloud (Intersection) ?