SIGIRR and TLR4

Number of citations of the paper that reports this interaction (PMID 12925853)
92

Data Source:
HPRD (in vivo)

		SIGIRR	TLR4
Gene Name		single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	toll-like receptor 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Integral Component Of Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Lipopolysaccharide Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Lipopolysaccharide Binding Lipopolysaccharide Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Chemokine Biosynthetic Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway B Cell Proliferation Involved In Immune Response Nitric Oxide Production Involved In Inflammatory Response MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Positive Regulation Of Platelet Activation Detection Of Fungus Positive Regulation Of B Cell Proliferation Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Interferon-gamma Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-23 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway T-helper 1 Type Immune Response Macrophage Activation Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Intestinal Epithelial Structure Maintenance Positive Regulation Of Macrophage Cytokine Production Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Mechanical Stimulus
Pathways		Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System	TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88:Mal cascade initiated on plasma membrane TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	24 interactors: BCL10 BTK CD14 CNPY4 DEFB4A HMGB1 HSP90B1 IRAK1 IRAK2 LY96 MAPK8IP3 MYD88 NOX4 RIPK2 RNF216 SERTAD1 SIGIRR SMAD3 SYK TICAM2 TIRAP TLR1 TLR5 TOLLIP
Entrez ID		59307	7099
HPRD ID		12018	04325
Ensembl ID		ENSG00000185187	ENSG00000136869
Uniprot IDs		C9JFX4 Q6IA17	O00206
PDB IDs			2Z62 2Z63 2Z65 2Z66 3FXI 3UL7 3UL8 3UL9 3ULA 4G8A
Enriched GO Terms of Interacting Partners?		MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Regulation Of Innate Immune Response Immune Response Response To Molecule Of Bacterial Origin Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Positive Regulation Of Interleukin-8 Production Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Immune Response-regulating Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Bacterium Positive Regulation Of Interleukin-12 Production Cellular Response To Interleukin-1 Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Immune System Process Regulation Of Interleukin-12 Production MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Defense Response Regulation Of MAP Kinase Activity Response To Other Organism Response To Interleukin-1 Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Kinase Activity Response To Biotic Stimulus Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Kinase Activity	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Inflammatory Response Innate Immune Response Regulation Of Innate Immune Response Defense Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Immune Response-regulating Signaling Pathway Response To Other Organism Response To Biotic Stimulus Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune Response Response To Bacterium Regulation Of Immune Response Cellular Response To Molecule Of Bacterial Origin Regulation Of Cytokine Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Stress Regulation Of Immune System Process Response To Molecule Of Bacterial Origin Immune System Process Positive Regulation Of Immune System Process Response To External Stimulus I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Cellular Response To Lipopolysaccharide Regulation Of Protein Metabolic Process Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Response To Organic Substance MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Toll-like Receptor 3 Signaling Pathway JNK Cascade Cellular Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Regulation Of Phosphorylation Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction
Tagcloud ?		1r acting affects autoimmune c3 c4 cd4 circulating correlation cytometer erythematosus esr explored glucocorticoid hour immunoglobulin lupus mononuclear nephritis pbmcs percentages quantified scr sle sledai summary tlr z	bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr1 tlr9 tlrs toll vff vffs vocal
Tagcloud (Difference) ?		1r acting affects autoimmune c3 c4 cd4 circulating correlation cytometer erythematosus esr explored glucocorticoid hour immunoglobulin lupus mononuclear nephritis pbmcs percentages scr sle sledai summary tlr z	bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria respond responsiveness scar strategic supernatant tlr1 tlr9 tlrs toll vff vffs vocal
Tagcloud (Intersection) ?		quantified