TLR4 and NOX4

Number of citations of the paper that reports this interaction (PMID 15356101)
107

Data Source:
HPRD (in vitro, two hybrid)

		TLR4	NOX4
Gene Name		toll-like receptor 4	NADPH oxidase 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Lipopolysaccharide Receptor Complex Perinuclear Region Of Cytoplasm	Stress Fiber Nucleolus Mitochondrion Endoplasmic Reticulum Membrane Focal Adhesion Integral Component Of Membrane Apical Plasma Membrane NADPH Oxidase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Lipopolysaccharide Binding Lipopolysaccharide Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding	Nucleotide Binding Electron Carrier Activity NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activity Oxygen Sensor Activity Heme Binding Flavin Adenine Dinucleotide Binding Modified Amino Acid Binding
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway B Cell Proliferation Involved In Immune Response Nitric Oxide Production Involved In Inflammatory Response MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Positive Regulation Of Platelet Activation Detection Of Fungus Positive Regulation Of B Cell Proliferation Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Interferon-gamma Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-23 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway T-helper 1 Type Immune Response Macrophage Activation Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Intestinal Epithelial Structure Maintenance Positive Regulation Of Macrophage Cytokine Production Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Mechanical Stimulus	Cell Morphogenesis Response To Hypoxia Inflammatory Response Cell Aging Negative Regulation Of Cell Proliferation Positive Regulation Of Smooth Muscle Cell Migration Superoxide Anion Generation Positive Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Bone Resorption Homocysteine Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Oxidation-reduction Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Glucose Stimulus Cellular Response To Gamma Radiation Cellular Response To Transforming Growth Factor Beta Stimulus Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process
Pathways		TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88:Mal cascade initiated on plasma membrane TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		24 interactors: BCL10 BTK CD14 CNPY4 DEFB4A HMGB1 HSP90B1 IRAK1 IRAK2 LY96 MAPK8IP3 MYD88 NOX4 RIPK2 RNF216 SERTAD1 SIGIRR SMAD3 SYK TICAM2 TIRAP TLR1 TLR5 TOLLIP	1 interactors: TLR4
Entrez ID		7099	50507
HPRD ID		04325	09243
Ensembl ID		ENSG00000136869	ENSG00000086991
Uniprot IDs		O00206	B3KQ17 B7Z520 Q9NPH5
PDB IDs		2Z62 2Z63 2Z65 2Z66 3FXI 3UL7 3UL8 3UL9 3ULA 4G8A
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Inflammatory Response Innate Immune Response Regulation Of Innate Immune Response Defense Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Immune Response-regulating Signaling Pathway Response To Other Organism Response To Biotic Stimulus Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune Response Response To Bacterium Regulation Of Immune Response Cellular Response To Molecule Of Bacterial Origin Regulation Of Cytokine Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Stress Regulation Of Immune System Process Response To Molecule Of Bacterial Origin Immune System Process Positive Regulation Of Immune System Process Response To External Stimulus I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Cellular Response To Lipopolysaccharide Regulation Of Protein Metabolic Process Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Response To Organic Substance MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Toll-like Receptor 3 Signaling Pathway JNK Cascade Cellular Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Regulation Of Phosphorylation Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction	Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Detection Of Fungus Negative Regulation Of Interleukin-23 Production Nitric Oxide Production Involved In Inflammatory Response Detection Of Lipopolysaccharide Intestinal Epithelial Structure Maintenance Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway B Cell Proliferation Involved In Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Platelet Activation Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Interferon-beta Biosynthetic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process I-kappaB Phosphorylation Maintenance Of Gastrointestinal Epithelium Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Tumor Necrosis Factor Biosynthetic Process Interferon-gamma Production Epithelial Structure Maintenance Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Production Of Molecular Mediator Involved In Inflammatory Response T-helper 1 Type Immune Response Detection Of Biotic Stimulus Macrophage Activation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Interleukin-10 Production Regulation Of Platelet Activation Positive Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Blood Coagulation Negative Regulation Of Interferon-gamma Production Defense Response To Gram-negative Bacterium Negative Regulation Of Interleukin-6 Production Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Coagulation Response To Fungus
Tagcloud ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr1 tlr9 tlrs toll vff vffs vocal	autophagy cardiomyocytes clarified dedicated deprivation discuss elimination endoplasmic enzymatic exist far ischaemia isoforms minimally modulate nadph nox2 nutrient oxidase past pathogens perk phagocytes regulate representing reticulum ros signalling
Tagcloud (Difference) ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr1 tlr9 tlrs toll vff vffs vocal	autophagy cardiomyocytes clarified dedicated deprivation discuss elimination endoplasmic enzymatic exist far ischaemia isoforms minimally modulate nadph nox2 nutrient oxidase past pathogens perk phagocytes regulate representing reticulum ros signalling
Tagcloud (Intersection) ?