SIGIRR and ENO2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SIGIRR	ENO2
Gene Name		single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	enolase 2 (gamma, neuronal)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Integral Component Of Membrane	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytosol Plasma Membrane Perikaryon Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Magnesium Ion Binding Phosphopyruvate Hydratase Activity
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Chemokine Biosynthetic Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Small Molecule Metabolic Process
Pathways		Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	23 interactors: A2M ACD ANXA11 C16orf45 C6orf47 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C
Entrez ID		59307	2026
HPRD ID		12018	00573
Ensembl ID		ENSG00000185187	ENSG00000111674
Uniprot IDs		C9JFX4 Q6IA17	P09104 Q6FHV6
PDB IDs			1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS
Enriched GO Terms of Interacting Partners?		MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Regulation Of Innate Immune Response Immune Response Response To Molecule Of Bacterial Origin Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Positive Regulation Of Interleukin-8 Production Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Immune Response-regulating Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Bacterium Positive Regulation Of Interleukin-12 Production Cellular Response To Interleukin-1 Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Immune System Process Regulation Of Interleukin-12 Production MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Defense Response Regulation Of MAP Kinase Activity Response To Other Organism Response To Interleukin-1 Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Kinase Activity Response To Biotic Stimulus Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Kinase Activity	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Mitotic Cell Cycle Process Organelle Organization Cell Division Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Platelet Degranulation Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Regulation Of Organelle Organization Cell Cycle Positive Regulation Of DNA Biosynthetic Process Cellular Component Assembly G2/M Transition Of Mitotic Cell Cycle RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Exocytosis Cell Cycle Process Positive Regulation Of DNA Metabolic Process Protein Localization To Chromosome Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Organelle Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Catalytic Activity Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Platelet Activation Cellular Localization Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Protein ADP-ribosylation
Tagcloud ?		1r acting affects autoimmune c3 c4 cd4 circulating correlation cytometer erythematosus esr explored glucocorticoid hour immunoglobulin lupus mononuclear nephritis pbmcs percentages quantified scr sle sledai summary tlr z	begin differentially dige enolase failures gondii gra7 hypothetical imc1 mic2 naturally parasite proteomics pyrimethamine qrt rh rhoptry rop2 rop2a spectrometer spots strains sulfadiazine sulfonamide tga tgh toxoplasma toxoplasmosis undertook
Tagcloud (Difference) ?		1r acting affects autoimmune c3 c4 cd4 circulating correlation cytometer erythematosus esr explored glucocorticoid hour immunoglobulin lupus mononuclear nephritis pbmcs percentages quantified scr sle sledai summary tlr z	begin differentially dige enolase failures gondii gra7 hypothetical imc1 mic2 naturally parasite proteomics pyrimethamine qrt rh rhoptry rop2 rop2a spectrometer spots strains sulfadiazine sulfonamide tga tgh toxoplasma toxoplasmosis undertook
Tagcloud (Intersection) ?