SIGIRR and TLR5

Number of citations of the paper that reports this interaction (PMID 12925853)
92

Data Source:
HPRD (in vivo)

		SIGIRR	TLR5
Gene Name		single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	toll-like receptor 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Chemokine Biosynthetic Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Male Gonad Development Positive Regulation Of Interleukin-8 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Defense Response To Bacterium Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus
Pathways		Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System	Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	5 interactors: MYD88 RNF216 SIGIRR TLR1 TLR4
Entrez ID		59307	7100
HPRD ID		12018	04326
Ensembl ID		ENSG00000185187	ENSG00000187554
Uniprot IDs		C9JFX4 Q6IA17	O60602
PDB IDs			1P95 3J0A
Enriched GO Terms of Interacting Partners?		MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Regulation Of Innate Immune Response Immune Response Response To Molecule Of Bacterial Origin Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Positive Regulation Of Interleukin-8 Production Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Immune Response-regulating Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Bacterium Positive Regulation Of Interleukin-12 Production Cellular Response To Interleukin-1 Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Immune System Process Regulation Of Interleukin-12 Production MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Defense Response Regulation Of MAP Kinase Activity Response To Other Organism Response To Interleukin-1 Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Kinase Activity Response To Biotic Stimulus Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Kinase Activity	Regulation Of Cytokine Biosynthetic Process Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Activation Of Innate Immune Response Detection Of Molecule Of Bacterial Origin Cellular Response To Molecule Of Bacterial Origin Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Detection Of Biotic Stimulus Macrophage Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Response To Fungus Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Regulation Of Immune System Process Defense Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Immune Response-regulating Signaling Pathway Response To Bacterium Cellular Response To Mechanical Stimulus Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune Response Toll-like Receptor 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Detection Of Fungus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Other Organism Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Biotic Stimulus
Tagcloud ?		1r acting affects autoimmune c3 c4 cd4 circulating correlation cytometer erythematosus esr explored glucocorticoid hour immunoglobulin lupus mononuclear nephritis pbmcs percentages quantified scr sle sledai summary tlr z	adjuvanted alum anticocaine antihapten avenue benchmark boosting c4 cocaine conjugates exploration flagellin flic gne hampered hapten immunogenicity impacting inadequate indirectly klh liposomal lives millions mpla nlrc4 problematic reasoning tactics
Tagcloud (Difference) ?		1r acting affects autoimmune c3 cd4 circulating correlation cytometer erythematosus esr explored glucocorticoid hour immunoglobulin lupus mononuclear nephritis pbmcs percentages quantified scr sle sledai summary tlr z	adjuvanted alum anticocaine antihapten avenue benchmark boosting cocaine conjugates exploration flagellin flic gne hampered hapten immunogenicity impacting inadequate indirectly klh liposomal lives millions mpla nlrc4 problematic reasoning tactics
Tagcloud (Intersection) ?		c4