RAD51D and BLM

Number of citations of the paper that reports this interaction (PMID 12975363)
26

Data Source:
BioGRID (far western blotting)
HPRD (in vivo, in vitro)

		RAD51D	BLM
Gene Name		RAD51 paralog D	Bloom syndrome, RecQ helicase-like
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nuclear Chromosome Chromosome, Telomeric Region Lateral Element Male Germ Cell Nucleus Nucleus Replication Fork Nucleolus Cytoplasm Nuclear Matrix PML Body Pronucleus
	Molecular Function	Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Gamma-tubulin Binding	Bubble DNA Binding P53 Binding Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Helicase Activity Four-way Junction Helicase Activity ATPase Activity Annealing Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Reciprocal Meiotic Recombination Strand Invasion	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Strand Renaturation DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To X-ray Replication Fork Processing DNA Duplex Unwinding Positive Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Recombination Negative Regulation Of Mitotic Recombination Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Replication Fork Protection Regulation Of Binding Protein Oligomerization Negative Regulation Of Cell Division Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin
Pathways			Meiotic recombination
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: AMOTL2 BLM C1orf94 CEP57L1 IKZF1 IKZF3 KIFC3 KRT15 LNX1 LZTS2 PRDM14 RAD51B RAD51C SWSAP1 XRCC2 XRCC3 ZSWIM7	33 interactors: ATM ATR ATRX BRIP1 CASP3 CHAF1A CHEK1 FANCD2 FEN1 MCRS1 MIB1 MLH1 MX1 PSMD3 RAD51 RAD51D RNF8 RPA1 SMC1A SUMO1 SUMO2 SUMO3 SYN1 TERF1 TERF2 TOP3A TOPBP1 TP53 TP53BP1 TRIM49 UBE2I UPF2 WRN
Entrez ID		5892	641
HPRD ID		04261	05211
Ensembl ID		ENSG00000185379	ENSG00000197299
Uniprot IDs		O75771	P54132
PDB IDs		2KZ3	2KV2 2RRD
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Organelle Organization Positive Regulation Of Mitotic Cell Cycle DNA Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle Nucleobase-containing Compound Metabolic Process Meiotic Nuclear Division Response To X-ray Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Meiotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Reciprocal Meiotic Recombination Positive Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Neutrophil Differentiation Histone H3-R26 Methylation Inner Cell Mass Cell Fate Commitment Nitrogen Compound Metabolic Process Positive Regulation Of Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Microtubule-based Process Female Meiosis Sister Chromatid Cohesion Resolution Of Mitotic Recombination Intermediates Resolution Of Recombination Intermediates Strand Invasion DNA Catabolic Process, Endonucleolytic Protein Stabilization Zonula Adherens Maintenance Cellular Response To Camptothecin Cellular Response To Hydroxyurea Cellular Macromolecule Catabolic Process Regulation Of Lymphocyte Activation Meiosis I Lymphocyte Activation Response To Camptothecin Negative Regulation Of Mitotic Recombination Microtubule Cytoskeleton Organization	Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Repair Cellular Response To Stress Double-strand Break Repair Chromosome Organization DNA Recombination Cell Cycle Response To Stress Cell Cycle Process Organelle Organization Response To Radiation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Aging Telomere Maintenance Nitrogen Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of DNA Metabolic Process Meiotic Nuclear Division Meiotic Cell Cycle Cell Cycle Checkpoint Response To Abiotic Stimulus Replicative Senescence Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of DNA Replication Response To Gamma Radiation Cellular Response To Ionizing Radiation Regulation Of DNA Replication Response To UV Cellular Response To Radiation Mitotic Cell Cycle Protein Sumoylation Metabolic Process DNA Damage Checkpoint DNA Conformation Change Response To Stimulus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Aging Regulation Of Cell Cycle Process
Tagcloud ?		altogether anything atm brca2 brip1 chek2 confer dysfunctional exons germline harbor heritability hrr inherited junction missense palb2 paralogs postulated private silent splice substitutions tolerates unexplained variants xrcc2	bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol
Tagcloud (Difference) ?		altogether anything atm brca2 brip1 chek2 confer dysfunctional exons germline harbor heritability hrr inherited junction missense palb2 paralogs postulated private silent splice substitutions tolerates unexplained variants xrcc2	bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol
Tagcloud (Intersection) ?