RIPK2 and BIRC3

Number of citations of the paper that reports this interaction (PMID 19464198)
59

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study)

		RIPK2	BIRC3
Gene Name		receptor-interacting serine-threonine kinase 2	baculoviral IAP repeat containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Vesicle Protein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Membrane Raft
	Molecular Function	Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding LIM Domain Binding Protein Homodimerization Activity CARD Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Adaptive Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Inflammatory Response Signal Transduction I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Positive Regulation Of Alpha-beta T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Response To Interleukin-1 Response To Interleukin-12 Response To Interleukin-18 Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Spermatogenesis Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Negative Regulation Of Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Innate Immune Response Regulation Of Inflammatory Response Protein Heterooligomerization Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Downstream TCR signaling p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 activated TAK1 mediates p38 MAPK activation Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Crohn's disease ( 23128233) Leprosy ( 20018961)	MRI atrophy measures ( 21116278) Prostate cancer ( 23535732)
Protein-Protein Interactions		31 interactors: BCL10 BIRC2 BIRC3 CARD16 CARD6 CASP1 CASP8 CD40 CFLAR CHUK IKBKG IRAK1 KDM3A LRRK2 MAVS NGFR NOD1 NOD2 PELI3 PRMT2 SMAD4 SMURF1 TLR2 TLR4 TNFRSF1A TRAF1 TRAF2 TRAF5 TRAF6 UBE2I XIAP	37 interactors: BCL10 BIRC5 CASP3 CASP7 CASP9 CD40 CYFIP2 DIABLO DZIP3 GSPT1 HAX1 HTRA2 IKBKE IKBKG MAP3K14 MBTPS1 PACS2 RAF1 RCHY1 RIPK1 RIPK2 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 TRAF3 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19
Entrez ID		8767	330
HPRD ID		04585	03426
Ensembl ID		ENSG00000104312	ENSG00000023445
Uniprot IDs		O43353	Q13489
PDB IDs			2UVL 3EB5 3EB6 3M0A 3M0D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Signal Transduction Regulation Of Cell Death Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Apoptotic Process Regulation Of Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cytokine Production Cell Death Death Positive Regulation Of Cellular Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cytokine Production Response To Bacterium Apoptotic Process Positive Regulation Of Immune Response Programmed Cell Death Regulation Of Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Other Organism Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Defense Response Response To Biotic Stimulus Positive Regulation Of Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Negative Regulation Of Cell Death Toll-like Receptor 2 Signaling Pathway Innate Immune Response	Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Activation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Immune System Process Apoptotic Process Programmed Cell Death Regulation Of Immune Response Cell Death Death Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Immune System Process Regulation Of Cysteine-type Endopeptidase Activity Defense Response Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Immune Response Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Stress Positive Regulation Of Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Immune System Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		altogether appealing approved arthritis bowel conjunction crohn diagnostics drastically excessive fda gefitinib ibd ileitis improves nod1 nod2 optimization peptidoglycan peritonitis pharmaceuticals pharmacologic potently predicting productive rationale sarcoidosis sensors transduces	binet biology briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Difference) ?		altogether appealing approved arthritis bowel conjunction crohn diagnostics drastically excessive fda gefitinib ibd ileitis improves nod1 nod2 optimization peptidoglycan peritonitis pharmaceuticals pharmacologic potently predicting productive rationale sarcoidosis sensors transduces	binet biology briefer chinese cll concurrent confounded consecutive descent diverse etiology european fludarabine frequencies germline give ighv insights lymphocytic mutated mutations myd88 notch1 persons predominately sf3b1 stratification tp53 un
Tagcloud (Intersection) ?