PPL and PPHLN1

Number of citations of the paper that reports this interaction (PMID 12853457)
5

Data Source:
HPRD (two hybrid)

		PPL	PPHLN1
Gene Name		periplakin	periphilin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytoskeleton Plasma Membrane Desmosome Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding	Poly(A) RNA Binding
	Biological Process	Keratinization	Keratinization
Pathways
Drugs
Diseases
GWAS		Lung cancer-asbestos exposure interaction ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		22 interactors: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 OPRM1 PPHLN1 RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1	20 interactors: APP BCL2L1 BRCA1 CASP5 CCDC57 CDC37 CDK6 MTUS2 NAGK PAXIP1 PPL SEPT8 SNCAIP SQSTM1 TGM2 TOMM20 TP53BP2 TSGA10 UFD1L VIM
Entrez ID		5493	51535
HPRD ID		04187	10488
Ensembl ID		ENSG00000118898	ENSG00000134283
Uniprot IDs		O60437	B7Z8L1 E9PAX8 F8W6A0 Q8NEY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Epithelial Cell Differentiation Epithelium Development Protein Trimerization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Keratinization Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Execution Phase Of Apoptosis Keratinocyte Differentiation Tissue Development Epidermis Development Regulation Of Intracellular Signal Transduction Protein Homotrimerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Response To Food Positive Regulation Of Cell Death Apoptotic Signaling Pathway Glycogen Biosynthetic Process Developmental Process Epidermal Cell Differentiation Response To Cytokine Tumor Necrosis Factor-mediated Signaling Pathway Cell Differentiation Involved In Embryonic Placenta Development Cell Differentiation Anatomical Structure Development Protein K63-linked Ubiquitination Lens Fiber Cell Differentiation Positive Regulation Of Sodium Ion Transport Protein Polyubiquitination Regulation Of Ion Transmembrane Transport Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Polysaccharide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Neuron Death Positive Regulation Of Phosphorylation Negative Regulation Of Ion Transmembrane Transport Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance	Response To Ionizing Radiation Apoptotic Process Programmed Cell Death Cell Death Death Response To Radiation Positive Regulation Of Histone H3-K4 Methylation Regulation Of Cell Cycle Positive Regulation Of Histone Acetylation Signal Transduction By P53 Class Mediator Developmental Process Regulation Of Histone H3-K4 Methylation Response To Abiotic Stimulus Positive Regulation Of Peptidyl-lysine Acetylation Apoptotic Signaling Pathway Organ Development Positive Regulation Of Protein Acetylation Astrocyte Development Multicellular Organismal Development Anatomical Structure Development System Development Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cell Cycle Positive Regulation Of Histone Methylation Intrinsic Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Astrocyte Differentiation Regulation Of Histone Acetylation Central Nervous System Development Positive Regulation Of Gene Expression Regulation Of Histone Methylation Neuron Apoptotic Process Positive Regulation Of Histone H4-K20 Methylation Cell Dedifferentiation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Histone H4-K16 Acetylation Apoptotic Process In Bone Marrow Regulation Of Signaling Neuron Death Positive Regulation Of Histone Modification Execution Phase Of Apoptosis Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Synaptic Growth At Neuromuscular Junction Positive Regulation Of Histone H3-K9 Acetylation N-acetylmannosamine Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Differentiation Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage
Tagcloud ?		32p aug carboxyl codons dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding
Tagcloud (Difference) ?		32p aug carboxyl codons dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding
Tagcloud (Intersection) ?