PPL

Gene Name		periplakin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytoskeleton Plasma Membrane Desmosome Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Keratinization
Pathways
Drugs
Diseases
GWAS		Lung cancer-asbestos exposure interaction ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-protein Interactions		22 interactors: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 OPRM1 PPHLN1 RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1
Entrez ID		5493
HPRD ID		04187
Ensembl ID		ENSG00000118898
Uniprot IDs		O60437
PDB IDs
Enriched GO Terms of Interacting Partners?		Epithelial Cell Differentiation Epithelium Development Protein Trimerization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Keratinization Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Execution Phase Of Apoptosis Keratinocyte Differentiation Tissue Development Epidermis Development Regulation Of Intracellular Signal Transduction Protein Homotrimerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Response To Food Positive Regulation Of Cell Death Apoptotic Signaling Pathway Glycogen Biosynthetic Process Developmental Process Epidermal Cell Differentiation Response To Cytokine Tumor Necrosis Factor-mediated Signaling Pathway Cell Differentiation Involved In Embryonic Placenta Development Cell Differentiation Anatomical Structure Development Protein K63-linked Ubiquitination Lens Fiber Cell Differentiation Positive Regulation Of Sodium Ion Transport Protein Polyubiquitination Regulation Of Ion Transmembrane Transport Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Polysaccharide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Neuron Death Positive Regulation Of Phosphorylation Negative Regulation Of Ion Transmembrane Transport Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance
Tagcloud ?		32p aug carboxyl codons dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding