PPL and CEP57L1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PPL	CEP57L1
Gene Name		periplakin	centrosomal protein 57kDa-like 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytoskeleton Plasma Membrane Desmosome Extracellular Vesicular Exosome	Cellular_component Cytoplasm Microtubule Organizing Center Microtubule
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding	Molecular_function Microtubule Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Keratinization	Biological_process Microtubule Anchoring
Pathways
Drugs
Diseases
GWAS		Lung cancer-asbestos exposure interaction ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000)	Prostate cancer ( 23535732)
Protein-Protein Interactions		22 interactors: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 OPRM1 PPHLN1 RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1	69 interactors: ALOX5 AP1M1 ARNT2 BRCA1 BYSL C6orf165 CALCOCO2 CARD9 CCDC102B CCDC136 CCDC57 CDR2 CEP44 CEP55 CEP63 CEP70 DISC1 DYDC1 EXOC8 FAM161A FAM9B GADD45G GOLGA1 GOLGA2 HAUS1 HDDC3 HGS IKZF1 KATNAL1 KIFC3 KLC3 KLC4 KRT13 KRT19 KRT31 KRT38 KRT40 LENG1 LMO3 LZTS2 MAGEA1 MAGEA2B MDFI MEOX2 MFAP1 MID2 MORF4L1 MTUS2 MYO15B NUP62 PKN1 PNMA5 PPL RAD51D RINT1 ROPN1 SNAP47 SNAPC3 SPERT TAB3 TCEB3 TFIP11 TRAF2 TRAPPC2L TRIM54 TRIP6 TSGA10 TXLNA TXLNB
Entrez ID		5493	285753
HPRD ID		04187	10792
Ensembl ID		ENSG00000118898	ENSG00000183137
Uniprot IDs		O60437	G5E992 Q8IYX8
PDB IDs
Enriched GO Terms of Interacting Partners?		Epithelial Cell Differentiation Epithelium Development Protein Trimerization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Keratinization Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Execution Phase Of Apoptosis Keratinocyte Differentiation Tissue Development Epidermis Development Regulation Of Intracellular Signal Transduction Protein Homotrimerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Response To Food Positive Regulation Of Cell Death Apoptotic Signaling Pathway Glycogen Biosynthetic Process Developmental Process Epidermal Cell Differentiation Response To Cytokine Tumor Necrosis Factor-mediated Signaling Pathway Cell Differentiation Involved In Embryonic Placenta Development Cell Differentiation Anatomical Structure Development Protein K63-linked Ubiquitination Lens Fiber Cell Differentiation Positive Regulation Of Sodium Ion Transport Protein Polyubiquitination Regulation Of Ion Transmembrane Transport Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Polysaccharide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Neuron Death Positive Regulation Of Phosphorylation Negative Regulation Of Ion Transmembrane Transport Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance	Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Organelle Organization Microtubule-based Process Regulation Of Stress-activated MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Cycle Regulation Of Signal Transduction Microtubule Severing Regulation Of Signaling I-kappaB Kinase/NF-kappaB Signaling Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Microtubule Cytoskeleton Organization Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Cellular Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Spindle Assembly Positive Regulation Of Protein Modification Process Regulation Of JUN Kinase Activity Double-strand Break Repair Via Homologous Recombination Recombinational Repair JNK Cascade Negative Regulation Of Protein Acetylation Centrosome Organization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of MAP Kinase Activity Mitotic Cell Cycle Positive Regulation Of Transferase Activity Microtubule Organizing Center Organization Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Cycle Process Cell Differentiation Involved In Embryonic Placenta Development Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Histone H4-K20 Methylation Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Spliceosomal Complex Disassembly Positive Regulation Of Histone H4-K16 Acetylation Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Tagcloud ?		32p aug carboxyl codons dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding
Tagcloud (Difference) ?		32p aug carboxyl codons dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding
Tagcloud (Intersection) ?