UBE2R2 and DTX3L

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2R2	DTX3L
Gene Name		ubiquitin-conjugating enzyme E2R 2	deltex 3 like, E3 ubiquitin ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Histone Binding
	Biological Process	Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination	Double-strand Break Repair Cellular Response To DNA Damage Stimulus Histone Monoubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		17 interactors: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 DTX3L DZIP3 FBXW5 INF2 MEOX1 PNPLA2 RBX1 RNF113B UBA1 UBC	19 interactors: DTX1 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W
Entrez ID		54926	151636
HPRD ID		15602	16843
Ensembl ID		ENSG00000107341	ENSG00000163840
Uniprot IDs		Q712K3	Q8TDB6
PDB IDs			3PG6
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Protein Polyubiquitination Catabolic Process Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Metabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Mitotic Spindle Checkpoint Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Cycle Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Wnt Signaling Pathway Rhythmic Process	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Protein K63-linked Ubiquitination Protein Monoubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein K29-linked Ubiquitination Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Innate Immune Response ISG15-protein Conjugation Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Stress Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Positive Regulation Of Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Mitotic Spindle Assembly Checkpoint
Tagcloud ?			artd artd8 artd9 bal bal1 bbap chemo deltex diphtheria du145 hpe il4 immunoprecipitations irf1 lncap macrodomain mono mpca parp14 parp9 pc3 proficient repressors ribosyltransferase ribosyltransferases rwpe1 stat1 stat6
Tagcloud (Difference) ?			artd artd8 artd9 bal bal1 bbap chemo deltex diphtheria du145 hpe il4 immunoprecipitations irf1 lncap macrodomain mono mpca parp14 parp9 pc3 proficient repressors ribosyltransferase ribosyltransferases rwpe1 stat1 stat6
Tagcloud (Intersection) ?