DTX3L and UBE2W

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		DTX3L	UBE2W
Gene Name		deltex 3 like, E3 ubiquitin ligase	ubiquitin-conjugating enzyme E2W (putative)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Histone Binding	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Double-strand Break Repair Cellular Response To DNA Damage Stimulus Histone Monoubiquitination	DNA Repair Protein Monoubiquitination Misfolded Or Incompletely Synthesized Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Protein-Protein Interactions		19 interactors: DTX1 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W	69 interactors: AKR1C3 AMFR BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MARCH3 MARCH5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF185 RNF2 RNF26 RNF4 RNF5 RNF8 ROPN1 STUB1 TOPORS TRIM17 TRIM2 TRIM27 TRIM31 TRIM35 TRIM39 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF4
Entrez ID		151636	55284
HPRD ID		16843	07724
Ensembl ID		ENSG00000163840	ENSG00000104343
Uniprot IDs		Q8TDB6	Q96B02 Q96FI0
PDB IDs		3PG6	2A7L
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Protein K63-linked Ubiquitination Protein Monoubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein K29-linked Ubiquitination Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Innate Immune Response ISG15-protein Conjugation Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Stress Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Positive Regulation Of Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Mitotic Spindle Assembly Checkpoint	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Cellular Metabolic Process Protein K48-linked Ubiquitination Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Metabolic Process Cellular Response To Stress Catabolic Process Protein Monoubiquitination Response To Stress Cellular Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Viral Release From Host Cell Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Ubiquitination Negative Regulation Of Viral Release From Host Cell DNA Repair Negative Regulation Of Viral Transcription Proteolysis Apoptotic Process Regulation Of Gene Expression By Genetic Imprinting Regulation Of Viral Transcription Programmed Cell Death Negative Regulation Of Viral Process Regulation Of Viral Process Cell Death Death Positive Regulation Of Organelle Organization Genetic Imprinting Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Histone Methylation Histone Ubiquitination Cellular Response To Stimulus
Tagcloud ?		artd artd8 artd9 bal bal1 bbap chemo deltex diphtheria du145 hpe il4 immunoprecipitations irf1 lncap macrodomain mono mpca parp14 parp9 pc3 proficient repressors ribosyltransferase ribosyltransferases rwpe1 stat1 stat6	advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages mono monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured
Tagcloud (Difference) ?		artd artd8 artd9 bal bal1 bbap chemo deltex diphtheria du145 hpe il4 immunoprecipitations irf1 lncap macrodomain mpca parp14 parp9 pc3 proficient repressors ribosyltransferase ribosyltransferases rwpe1 stat1 stat6	advance amines chemically cleave cleaving deubiquitylating displaying dub dubs fusions homopolymers hydrolase isopeptide k11 l3 linkage linkages monoubiquitylation preference reversal striking sumo2 synthesised topologically ubiquitylation uch unstructured
Tagcloud (Intersection) ?		mono