DTX3L and PHF7

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		DTX3L	PHF7
Gene Name		deltex 3 like, E3 ubiquitin ligase	PHD finger protein 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Microtubule Organizing Center
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Histone Binding	Zinc Ion Binding
	Biological Process	Double-strand Break Repair Cellular Response To DNA Damage Stimulus Histone Monoubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		19 interactors: DTX1 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W	15 interactors: APP ARIH2 DTX3L HIST3H3 IKBKG MDM2 RNF111 RNF14 RNF34 SRPK1 TRIM26 TRIM41 UBE2D4 USP1 USP15
Entrez ID		151636	51533
HPRD ID		16843	15127
Ensembl ID		ENSG00000163840	ENSG00000010318
Uniprot IDs		Q8TDB6	Q9BWX1 Q9NS08
PDB IDs		3PG6
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Protein K63-linked Ubiquitination Protein Monoubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein K29-linked Ubiquitination Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Innate Immune Response ISG15-protein Conjugation Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Stress Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Positive Regulation Of Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Mitotic Spindle Assembly Checkpoint	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Polyubiquitination Protein Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Intracellular Receptor Signaling Pathway Cellular Macromolecule Catabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Innate Immune Response Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Metabolic Process Protein K63-linked Ubiquitination Proteolysis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Endopeptidase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Peptidase Activity Cellular Response To UV-C Cellular Response To Vitamin B1 Regulation Of Signal Transduction Immune Response Regulation Of Nitrogen Compound Metabolic Process Defense Response Negative Regulation Of Viral Process Response To Light Stimulus Negative Regulation Of Proteolysis Regulation Of Oxygen Metabolic Process Synaptic Growth At Neuromuscular Junction Histone H2B Conserved C-terminal Lysine Deubiquitination Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		artd artd8 artd9 bal bal1 bbap chemo deltex diphtheria du145 hpe il4 immunoprecipitations irf1 lncap macrodomain mono mpca parp14 parp9 pc3 proficient repressors ribosyltransferase ribosyltransferases rwpe1 stat1 stat6	ablates associates dimethyl drosophila ectopic eggs establishment exhibits finger gametogenesis germ germline h3k4me2 homologs identity male phd preference reader rescues sexual soma sperm spermatogenesis spermatogonia strikingly tails testis xx
Tagcloud (Difference) ?		artd artd8 artd9 bal bal1 bbap chemo deltex diphtheria du145 hpe il4 immunoprecipitations irf1 lncap macrodomain mono mpca parp14 parp9 pc3 proficient repressors ribosyltransferase ribosyltransferases rwpe1 stat1 stat6	ablates associates dimethyl drosophila ectopic eggs establishment exhibits finger gametogenesis germ germline h3k4me2 homologs identity male phd preference reader rescues sexual soma sperm spermatogenesis spermatogonia strikingly tails testis xx
Tagcloud (Intersection) ?