PLD2 and PIP5K1A

Number of citations of the paper that reports this interaction (PMID 11032811)
22

Data Source:
HPRD (in vitro, in vivo)

		PLD2	PIP5K1A
Gene Name		phospholipase D2	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Brush Border Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Nuclear Speck Lamellipodium Ruffle Membrane
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Kinase Binding
	Biological Process	G-protein Coupled Receptor Internalization Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Glycerophospholipid Biosynthetic Process	Phospholipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Cell Migration Keratinocyte Differentiation Actin Cytoskeleton Reorganization Activation Of Rac GTPase Activity Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Focal Adhesion Assembly Cell Chemotaxis Protein Targeting To Plasma Membrane Ruffle Assembly
Pathways		Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System	Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS		Sphingolipid levels ( 22359512)
Protein-Protein Interactions		26 interactors: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A LCK MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1	11 interactors: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 PIP5KL1 PLD1 PLD2 TEC
Entrez ID		5338	8394
HPRD ID		03857	04470
Ensembl ID		ENSG00000129219	ENSG00000143398
Uniprot IDs		I3L2C9 O14939	A6PW57 Q99755
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Response To Wounding ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Stress Response To Organic Substance Endocytosis Cell Activation Vesicle-mediated Transport Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process T Cell Costimulation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Organonitrogen Compound Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Protein Autophosphorylation Immune Response Regulation Of Cellular Localization Regulation Of Cell-cell Adhesion Defense Response Regulation Of Intracellular Signal Transduction Response To Growth Factor Immune System Process Regulation Of Signaling Positive Regulation Of Phosphorylation Negative Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Transport Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Cellular Response To Organonitrogen Compound Regulation Of Cell Activation	Intracellular Signal Transduction Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Signaling Cell Communication Glycerophospholipid Metabolic Process Phosphatidylglycerol Biosynthetic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Organelle Localization Response To Oxidative Stress Cellular Copper Ion Homeostasis Signal Transduction Copper Ion Homeostasis Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Phosphate-containing Compound Metabolic Process Glycerophospholipid Biosynthetic Process Establishment Of Vesicle Localization Vesicle Localization Peptidyl-tyrosine Autophosphorylation B Cell Receptor Signaling Pathway Phospholipid Biosynthetic Process Lipid Metabolic Process Regulation Of Immune System Process Immune System Process Defense Response Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Neuron Apoptotic Process Cellular Localization Innate Immune Response Establishment Of Organelle Localization Neuron Death Exocytosis Regulation Of B Cell Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Neuromuscular Process Controlling Balance Cellular Lipid Metabolic Process Apoptotic Process Programmed Cell Death Organophosphate Metabolic Process Synaptic Growth At Neuromuscular Junction Cellular Response To Molecule Of Fungal Origin Cell Death Death Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Synaptic Vesicle Transport
Tagcloud ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld1 responsive se secretion tumorigenesis u87 utilize vegf	1q address akt3 amplified cascades copy cosmic encodes encoding enzymes evident extending iiibeta isozyme issue localize mutational neu numerically oncogenes phosphatidylinositol phosphoinositide pi3kc2b pi4kb quartet resource signalling structurally uncommon
Tagcloud (Difference) ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld1 responsive se secretion tumorigenesis u87 utilize vegf	1q address akt3 amplified cascades copy cosmic encodes encoding enzymes evident extending iiibeta isozyme issue localize mutational neu numerically oncogenes phosphatidylinositol phosphoinositide pi3kc2b pi4kb quartet resource signalling structurally uncommon
Tagcloud (Intersection) ?