PIP5K1A and PLD1

Number of citations of the paper that reports this interaction (PMID 11032811)
22

Data Source:
HPRD (in vivo)

		PIP5K1A	PLD1
Gene Name		phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	phospholipase D1, phosphatidylcholine-specific
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Nuclear Speck Lamellipodium Ruffle Membrane	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Kinase Binding	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	Phospholipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Cell Migration Keratinocyte Differentiation Actin Cytoskeleton Reorganization Activation Of Rac GTPase Activity Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Focal Adhesion Assembly Cell Chemotaxis Protein Targeting To Plasma Membrane Ruffle Assembly	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Defense Response To Gram-positive Bacterium
Pathways		Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism	Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 PIP5KL1 PLD1 PLD2 TEC	26 interactors: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL
Entrez ID		8394	5337
HPRD ID		04470	03855
Ensembl ID		ENSG00000143398	ENSG00000075651
Uniprot IDs		A6PW57 Q99755	Q13393 Q59EA4
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Signaling Cell Communication Glycerophospholipid Metabolic Process Phosphatidylglycerol Biosynthetic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Organelle Localization Response To Oxidative Stress Cellular Copper Ion Homeostasis Signal Transduction Copper Ion Homeostasis Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Phosphate-containing Compound Metabolic Process Glycerophospholipid Biosynthetic Process Establishment Of Vesicle Localization Vesicle Localization Peptidyl-tyrosine Autophosphorylation B Cell Receptor Signaling Pathway Phospholipid Biosynthetic Process Lipid Metabolic Process Regulation Of Immune System Process Immune System Process Defense Response Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Neuron Apoptotic Process Cellular Localization Innate Immune Response Establishment Of Organelle Localization Neuron Death Exocytosis Regulation Of B Cell Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Neuromuscular Process Controlling Balance Cellular Lipid Metabolic Process Apoptotic Process Programmed Cell Death Organophosphate Metabolic Process Synaptic Growth At Neuromuscular Junction Cellular Response To Molecule Of Fungal Origin Cell Death Death Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Synaptic Vesicle Transport	Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Cellular Response To Stimulus Regulation Of Body Fluid Levels Blood Coagulation Wound Healing Hemostasis Chemotaxis Cell Migration Platelet Activation Membrane Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Organization Cell Motility Response To Stimulus Response To Wounding Regulation Of Vesicle-mediated Transport Regulation Of Cellular Localization Actin Cytoskeleton Organization Actin Filament-based Process Vesicle-mediated Transport Cell Projection Organization Regulation Of Signaling Endocytosis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endocytosis Organelle Organization Cell Activation Signaling Cell Communication Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Cell Projection Assembly Anatomical Structure Morphogenesis Response To Stress Axon Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Apoptotic Process Neuron Projection Morphogenesis Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Cell Death
Tagcloud ?		1q address akt3 amplified cascades copy cosmic encodes encoding enzymes evident extending iiibeta isozyme issue localize mutational neu numerically oncogenes phosphatidylinositol phosphoinositide pi3kc2b pi4kb quartet resource signalling structurally uncommon	1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld2 responsive se secretion tumorigenesis u87 utilize vegf
Tagcloud (Difference) ?		1q address akt3 amplified cascades copy cosmic encodes encoding enzymes evident extending iiibeta isozyme issue localize mutational neu numerically oncogenes phosphatidylinositol phosphoinositide pi3kc2b pi4kb quartet resource signalling structurally uncommon	1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld2 responsive se secretion tumorigenesis u87 utilize vegf
Tagcloud (Intersection) ?