PLD2 and PEA15

Number of citations of the paper that reports this interaction (PMID 10926929)
14

Data Source:
HPRD (in vivo)

		PLD2	PEA15
Gene Name		phospholipase D2	phosphoprotein enriched in astrocytes 15
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Brush Border Membrane	Cytoplasm Microtubule Associated Complex
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Protein Binding
	Biological Process	G-protein Coupled Receptor Internalization Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Glycerophospholipid Biosynthetic Process	DNA Damage Checkpoint Transport Apoptotic Process Carbohydrate Transport Response To Morphine Negative Regulation Of Glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System
Drugs
Diseases
GWAS		Sphingolipid levels ( 22359512)
Protein-Protein Interactions		26 interactors: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A LCK MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1	18 interactors: ABCD4 AK9 AKT1 CAMK2G CASP8 FADD HTRA2 L1CAM LUC7L2 MAPK1 MAPK3 PANK4 PDPK1 PLD1 PLD2 PRKCA RPS6KA3 TERF2IP
Entrez ID		5338	8682
HPRD ID		03857	04579
Ensembl ID		ENSG00000129219	ENSG00000162734
Uniprot IDs		I3L2C9 O14939	B1AKZ3 B1AKZ4 B1AKZ5 Q15121
PDB IDs			4IZ5 4IZA
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Response To Wounding ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Stress Response To Organic Substance Endocytosis Cell Activation Vesicle-mediated Transport Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process T Cell Costimulation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Organonitrogen Compound Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Protein Autophosphorylation Immune Response Regulation Of Cellular Localization Regulation Of Cell-cell Adhesion Defense Response Regulation Of Intracellular Signal Transduction Response To Growth Factor Immune System Process Regulation Of Signaling Positive Regulation Of Phosphorylation Negative Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Transport Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Cellular Response To Organonitrogen Compound Regulation Of Cell Activation	Innate Immune Response Defense Response Positive Regulation Of Immune System Process Immune Response Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Stress Toll-like Receptor 4 Signaling Pathway Response To Temperature Stimulus Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Epidermal Growth Factor Response To Growth Factor Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Apoptotic Process Neurotrophin Signaling Pathway Programmed Cell Death Cell Activation Toll-like Receptor Signaling Pathway Response To Heat Response To Cytokine Cell Death Death Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Immune System Process Activation Of Innate Immune Response Positive Regulation Of Macrophage Differentiation Labyrinthine Layer Development Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Heat Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Cellular Response To Organic Substance Cellular Response To Mechanical Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Immune Response Platelet Activation
Tagcloud ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld1 responsive se secretion tumorigenesis u87 utilize vegf	abeta app astrocyte astrocytes astroglial clearance clues cortices degraded deposited differently enriched extracellularly milieu offer performing phagocytosed phagocytosis phosphoprotein precise proteomic ps1 quantified surrounding tag tandem understand upregulated verified
Tagcloud (Difference) ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld1 responsive se secretion tumorigenesis u87 utilize vegf	abeta app astrocyte astrocytes astroglial clearance clues cortices degraded deposited differently enriched extracellularly milieu offer performing phagocytosed phagocytosis phosphoprotein precise proteomic ps1 quantified surrounding tag tandem understand upregulated verified
Tagcloud (Intersection) ?