Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
SHC3 and NTRK1
Number of citations of the paper that reports this interaction (PMID
9507002
)
13
Data Source:
HPRD
(in vivo)
SHC3
NTRK1
Gene Name
SHC (Src homology 2 domain containing) transforming protein 3
neurotrophic tyrosine kinase, receptor, type 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Cytosol
Plasma Membrane
Endosome
Early Endosome
Late Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Axon
Dendrite
Cytoplasmic Vesicle
Early Endosome Membrane
Late Endosome Membrane
Neuronal Cell Body
Protein Complex
Receptor Complex
Molecular Function
Signal Transducer Activity
Protein Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Neurotrophin P75 Receptor Binding
Protein Binding
ATP Binding
Nerve Growth Factor Receptor Activity
Protein Homodimerization Activity
Neurotrophin Binding
Ephrin Receptor Binding
Nerve Growth Factor Binding
Biological Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Central Nervous System Development
Learning Or Memory
Insulin Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Neurotrophin TRK Receptor Signaling Pathway
Activation Of MAPKK Activity
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Activation Of Adenylate Cyclase Activity
Activation Of Phospholipase C Activity
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Axon Guidance
Aging
Learning Or Memory
Circadian Rhythm
Negative Regulation Of Cell Proliferation
Response To Radiation
Developmental Programmed Cell Death
Positive Regulation Of Neuron Projection Development
Response To Activity
Peptidyl-tyrosine Phosphorylation
Olfactory Nerve Development
B Cell Differentiation
Response To Nutrient Levels
Positive Regulation Of Ras GTPase Activity
Nerve Growth Factor Signaling Pathway
Mechanoreceptor Differentiation
Response To Drug
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Neuron Apoptotic Process
Response To Ethanol
Positive Regulation Of Angiogenesis
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Sympathetic Nervous System Development
Response To Axon Injury
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To Hydrostatic Pressure
Response To Electrical Stimulus
Positive Regulation Of Synaptic Transmission, Glutamatergic
Sertoli Cell Development
Axonogenesis Involved In Innervation
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Nicotine
Cellular Response To Nerve Growth Factor Stimulus
Pathways
Signalling to ERKs
Signalling by NGF
Insulin receptor signalling cascade
SHC-mediated signalling
SHC-related events triggered by IGF1R
SHC-related events
NGF signalling via TRKA from the plasma membrane
IGF1R signaling cascade
Signal attenuation
Signalling to RAS
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
SHC-mediated signalling
Signaling by Insulin receptor
Retrograde neurotrophin signalling
Signalling to ERKs
Signalling by NGF
Prolonged ERK activation events
Activation of TRKA receptors
NGF signalling via TRKA from the plasma membrane
ARMS-mediated activation
TRKA activation by NGF
PI3K/AKT activation
Signalling to RAS
Signalling to STAT3
NGF-independant TRKA activation
PLC-gamma1 signalling
Signalling to p38 via RIT and RIN
Frs2-mediated activation
Drugs
Amitriptyline
Imatinib
Regorafenib
Diseases
GWAS
Response to statin therapy (LDL-C) (
22331829
)
Protein-Protein Interactions
16 interactors:
ALK
APP
ARHGAP32
AXL
EGFR
ERBB2
ERBB3
FLT4
GOLGA2
GRB2
KRT31
KRT40
NTRK1
NTRK2
RET
SH3GL3
36 interactors:
ABL1
ARHGAP32
CAV1
CRK
DNAJA3
DYNLL1
FRS2
FRS3
GIPC1
GRB2
IRS1
IRS2
KIDINS220
MAPK3
MATK
NEDD4
NEDD4L
NGF
NGFR
NTF3
PIK3R1
PLCG1
PTPN1
PTPN11
RAP1A
RASA1
RASGRF1
RUSC1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SQSTM1
TRAF6
UBB
Entrez ID
53358
4914
HPRD ID
12005
01869
Ensembl ID
ENSG00000198400
Uniprot IDs
Q92529
P04629
PDB IDs
1HE7
1SHC
1WWA
1WWW
2IFG
4AOJ
4F0I
4GT5
Enriched GO Terms of Interacting Partners
?
Peptidyl-tyrosine Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Signal Transduction
Protein Phosphorylation
Peptidyl-amino Acid Modification
Regulation Of Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Neurogenesis
Nervous System Development
Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorylation
Phosphorylation
Phosphatidylinositol-mediated Signaling
Intracellular Signal Transduction
Cellular Response To Growth Factor Stimulus
Neuron Development
Response To Growth Factor
Regulation Of MAPK Cascade
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Catalytic Activity
Regulation Of Protein Phosphorylation
Generation Of Neurons
Anatomical Structure Development
Positive Regulation Of Protein Phosphorylation
Neuron Differentiation
Cell Surface Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Signal Transduction
System Development
Locomotion
Cell Development
Positive Regulation Of Synaptic Transmission, Glutamatergic
Developmental Process
Cellular Response To Organic Substance
Positive Regulation Of Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Signaling
Positive Regulation Of Protein Modification Process
Regulation Of Cellular Protein Metabolic Process
Cell Communication
Regulation Of Apoptotic Process
Movement Of Cell Or Subcellular Component
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Signaling
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Signal Transduction
Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway
Signaling
Regulation Of Kinase Activity
Cell Communication
Regulation Of Phosphorylation
Insulin Receptor Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Phosphorus Metabolic Process
Response To Organic Substance
Regulation Of Intracellular Signal Transduction
Cellular Response To Stimulus
Cellular Response To Insulin Stimulus
Regulation Of MAPK Cascade
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Catalytic Activity
Activation Of Protein Kinase Activity
Fc Receptor Signaling Pathway
Regulation Of Protein Kinase Activity
Cellular Response To Organonitrogen Compound
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Insulin
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Response To Peptide
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Phosphorylation
Response To Stimulus
Response To Peptide Hormone
Cellular Response To Fibroblast Growth Factor Stimulus
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Modification Process
Response To Fibroblast Growth Factor
Positive Regulation Of Catalytic Activity
Positive Regulation Of Kinase Activity
Tagcloud
?
aacr
accelerated
advancements
ago
approved
developments
discov
encodes
fda
fusions
harboring
next
oncd
oncogene
oncogenic
oncology
originally
precision
rationale
rearrangements
revisit
scientific
throughput
tpm3
transforming
trka
trkb
trkc
Tagcloud (Difference)
?
aacr
accelerated
advancements
ago
approved
developments
discov
encodes
fda
fusions
harboring
next
oncd
oncogene
oncogenic
oncology
originally
precision
rationale
rearrangements
revisit
scientific
throughput
tpm3
transforming
trka
trkb
trkc
Tagcloud (Intersection)
?