SHC3 and RET

Number of citations of the paper that reports this interaction (PMID 12242309)
11

Data Source:
HPRD (in vivo)

		SHC3	RET
Gene Name		SHC (Src homology 2 domain containing) transforming protein 3	ret proto-oncogene
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft
	Molecular Function	Signal Transducer Activity Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Calcium Ion Binding Protein Binding ATP Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Central Nervous System Development Learning Or Memory Insulin Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Neurotrophin TRK Receptor Signaling Pathway	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Response To Drug Neuron Maturation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signalling to ERKs Signalling by NGF Insulin receptor signalling cascade SHC-mediated signalling SHC-related events triggered by IGF1R SHC-related events NGF signalling via TRKA from the plasma membrane IGF1R signaling cascade Signal attenuation Signalling to RAS Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-mediated signalling Signaling by Insulin receptor
Drugs			Imatinib
Diseases
GWAS		Response to statin therapy (LDL-C) ( 22331829)	Hirschsprung's disease ( 19196962)
Protein-Protein Interactions		16 interactors: ALK APP ARHGAP32 AXL EGFR ERBB2 ERBB3 FLT4 GOLGA2 GRB2 KRT31 KRT40 NTRK1 NTRK2 RET SH3GL3	36 interactors: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG MAPK1 MAPK14 MAPK3 MAPK8 NOTCH2NL NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRF SHC1 SHC3 SRC STAT3
Entrez ID		53358	5979
HPRD ID		12005	01266
Ensembl ID			ENSG00000165731
Uniprot IDs		Q92529	P07949 Q9BTX6
PDB IDs			1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Protein Phosphorylation Peptidyl-amino Acid Modification Regulation Of Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Neurogenesis Nervous System Development Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Phosphorylation Phosphatidylinositol-mediated Signaling Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Neuron Development Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Generation Of Neurons Anatomical Structure Development Positive Regulation Of Protein Phosphorylation Neuron Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Signal Transduction System Development Locomotion Cell Development Positive Regulation Of Synaptic Transmission, Glutamatergic Developmental Process Cellular Response To Organic Substance Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Signaling Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Cell Communication Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Response To Peptide Response To Peptide Hormone Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Response To Organonitrogen Compound Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Stimulus Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signal Transduction Response To Hormone Positive Regulation Of Kinase Activity MAPK Cascade Regulation Of Immune Response Response To Wounding Ras Protein Signal Transduction Positive Regulation Of Transferase Activity
Tagcloud ?			coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc
Tagcloud (Difference) ?			coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc
Tagcloud (Intersection) ?