NTRK1 and RASGRF1

Number of citations of the paper that reports this interaction (PMID 15513915)
15

Data Source:
HPRD (in vivo)

		NTRK1	RASGRF1
Gene Name		neurotrophic tyrosine kinase, receptor, type 1	Ras protein-specific guanine nucleotide-releasing factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Neuronal Cell Body Protein Complex Receptor Complex	Cytosol Plasma Membrane Growth Cone Neuron Projection
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Nerve Growth Factor Binding	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Aging Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Developmental Programmed Cell Death Positive Regulation Of Neuron Projection Development Response To Activity Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development B Cell Differentiation Response To Nutrient Levels Positive Regulation Of Ras GTPase Activity Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Sympathetic Nervous System Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Axonogenesis Involved In Innervation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Nerve Growth Factor Stimulus	Signal Transduction Small GTPase Mediated Signal Transduction Synaptic Transmission Long-term Memory Cell Proliferation Neuron Projection Development Positive Regulation Of Ras GTPase Activity Activation Of Rac GTPase Activity Regulation Of Rac Protein Signal Transduction Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Pathways		Retrograde neurotrophin signalling Signalling to ERKs Signalling by NGF Prolonged ERK activation events Activation of TRKA receptors NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF PI3K/AKT activation Signalling to RAS Signalling to STAT3 NGF-independant TRKA activation PLC-gamma1 signalling Signalling to p38 via RIT and RIN Frs2-mediated activation	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events Ras activation uopn Ca2+ infux through NMDA receptor
Drugs		Amitriptyline Imatinib Regorafenib
Diseases
GWAS			Refractive error ( 23396134 20835236) RR interval (heart rate) ( 20031603)
Protein-Protein Interactions		36 interactors: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 FRS2 FRS3 GIPC1 GRB2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4 NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB	16 interactors: ADRBK1 CEBPA EHD4 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 TNK2 USP8 YWHAB YWHAE
Entrez ID		4914	5923
HPRD ID		01869	07362
Ensembl ID		ENSG00000198400	ENSG00000058335
Uniprot IDs		P04629	A8K270 F8VPA5 J3KQP9 Q13972 Q8IUU5
PDB IDs		1HE7 1SHC 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Kinase Activity Cell Communication Regulation Of Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Cellular Response To Insulin Stimulus Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Catalytic Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Positive Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Peptide Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Response To Stimulus Response To Peptide Hormone Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Response To Fibroblast Growth Factor Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity	Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Locomotion Positive Regulation Of Protein Modification Process Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Response To Organic Substance Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Ras Protein Signal Transduction Regulation Of Phosphorus Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Cell Migration Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Cell Motility Signal Transduction Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Mechanoreceptor Differentiation Signaling Regulation Of Cell Death Positive Regulation Of Organelle Organization Cell Communication Protein Autophosphorylation Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Positive Regulation Of Cell Differentiation Activation Of Protein Kinase Activity Defense Response
Tagcloud ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc	abundantly ampa arbor branch branches branching clamp corroborated dendritic div dominated dramatically electrophysiological heteromers miniature nmdars nr1nr2a nr1nr2b nr2 nr2a nr2b opportunity patch recordings refinement synapses tri ventral vscns
Tagcloud (Difference) ?		aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc	abundantly ampa arbor branch branches branching clamp corroborated dendritic div dominated dramatically electrophysiological heteromers miniature nmdars nr1nr2a nr1nr2b nr2 nr2a nr2b opportunity patch recordings refinement synapses tri ventral vscns
Tagcloud (Intersection) ?